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Using saltwater in agriculture has emerged as a solution that may help to address the issue of water supply for agriculture in light of current climate change. On the other side, salinity has a major impact on crop yield, particularly sensitive crops, and may have long-term implications for soil sustainability. Therefore, this study aimed to test the potential impact of a salt-tolerant bacterium, “ Stutzerimonas stutzeri PV248...
Design, synthesis, biological evaluation and computational studies of novel phthalimides as dual COX-2/5-LOX inhibitorsNARA Subscribed
Aiming to find effective anti-inflammatory agents, two new series of phthalimide derivatives 4a-h and 7a-f were synthesized and evaluated as inhibitors of COX and 5-LOX enzymes. The structures of all of the new compounds were confirmed by different spectroscopic analyses. The compounds in this study were designed with the intention of being moderately selective COX-2 inhibitors to avoid the negative effects of both highly sele...