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Oral Microbial Extracellular Vesicles as Novel Mediators of Alzheimer’s Pathogenesis: A Critical Review of the Periodontal–Brain AxisNARA Subscribed
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose origins extend beyond the brain. Chronic periodontitis has emerged as a modifiable risk factor, and extracellular vesicles (EVs) have recently been proposed as important mediators of the periodontal–brain axis. Periodontal pathogens such as Porphyromonas gingivalis ( P. gingivalis ) release bacterial EVs enriched with virulence factors including gingipa...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...