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Huntington’s disease (HD) is a movement disorder commonly recognized as being neurodegenerative. An increasing number of studies also show primary HD dysfunction in multiple tissues, consistent with the widespread expression of the mutated huntingtin gene. Studies of HD skeletal muscle have revealed membrane hyperexcitability and prolonged action potentials due to Cl – and K + channel dysfunction as well as decreased Ca 2+ rel...
Soil Respiration Responses to Prolonged Warming Vary Seasonally in a Subarctic GrasslandNARA Subscribed
Northern ecosystems are warming rapidly, but the effects on soil carbon (C) dynamics are not fully understood. In particular, it is unclear whether warming effects on soil respiration (SR) –the primary source of atmospheric CO 2 from terrestrial ecosystems– persist throughout the year or vary seasonally. While both summer and cold‐season processes shape annual soil C fluxes, the long cold season, which dominates high‐latitude...
Climate change is expected to increase the frequency and severity of droughts. These events, which can cause significant perturbations of terrestrial ecosystems and potentially long‐term impacts on ecosystem structure and functioning after the drought has subsided are often called ‘drought legacies’. While the immediate effects of drought on ecosystems have been comparatively well characterized, our broader understanding of dr...
Rationale Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Objective Our goal was to characterize the acute and chronic effect of memantine treatment on compulsive behavior and frontostriatal network structure and function in an adolescent rat model of compul...
Depolymerization of high‐molecular weight organic nitrogen (N) represents the major bottleneck of soil N cycling and yet is poorly understood compared to the subsequent inorganic N processes. Given the importance of organic N cycling and the rise of global change, we investigated the responses of soil protein depolymerization and microbial amino acid consumption to increased temperature, elevated atmospheric CO 2 , and drought...
Soil properties as key predictors of global grassland production: Have we overlooked micronutrients?NARA Subscribed
Fertilisation experiments have demonstrated that nutrient availability is a key determinant of biomass production and carbon sequestration in grasslands. However, the influence of nutrients in explaining spatial variation in grassland biomass production has rarely been assessed. Using a global dataset comprising 72 sites on six continents, we investigated which of 16 soil factors that shape nutrient availability associate most...
Warming and elevated CO 2 intensify drought and recovery responses of grassland carbon allocation to soil respirationNARA Subscribed
Photosynthesis and soil respiration represent the two largest fluxes of CO 2 in terrestrial ecosystems and are tightly linked through belowground carbon (C) allocation. Drought has been suggested to impact the allocation of recently assimilated C to soil respiration; however, it is largely unknown how drought effects are altered by a future warmer climate under elevated atmospheric CO 2 (eT_eCO 2 ). In a multifactor experiment...
Climatic and evolutionary contexts are required to infer plant life history strategies from functional traits at a global scaleNARA Subscribed
Life history strategies are fundamental to the ecology and evolution of organisms and are important for understanding extinction risk and responses to global change. Using global datasets and a multiple response modelling framework we show that trait‐climate interactions are associated with life history strategies for a diverse range of plant species at the global scale. Our modelling framework informs our understanding of tra...
Rainfall manipulation experiments as simulated by terrestrial biosphere models: Where do we stand?NARA Subscribed
Changes in rainfall amounts and patterns have been observed and are expected to continue in the near future with potentially significant ecological and societal consequences. Modelling vegetation responses to changes in rainfall is thus crucial to project water and carbon cycles in the future. In this study, we present the results of a new model‐data intercomparison project, where we tested the ability of 10 terrestrial biosph...
Understanding ecosystems of the future will require more than realistic climate change experiments – A response to Korell et al.NARA Subscribed
This article is a response to Korell et al., 26, 325–327 ; See also the Commentary on this article by Muller et al., 26, e4–e5 ; See also the response to this Letter to the Editor by Korell et al., 26, 328–329 .
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Traditional plant functional groups explain variation in economic but not size‐related traits across the tundra biomeNARA Subscribed
Aim Plant functional groups are widely used in community ecology and earth system modelling to describe trait variation within and across plant communities. However, this approach rests on the assumption that functional groups explain a large proportion of trait variation among species. We test whether four commonly used plant functional groups represent variation in six ecologically important plant traits. Location Tundra bio...
Spatial patterns and climate relationships of major plant traits in the New World differ between woody and herbaceous speciesNARA Subscribed
Aim Despite several recent efforts to map plant traits and to identify their climatic drivers, there are still major gaps. Global trait patterns for major functional groups, in particular, the differences between woody and herbaceous plants, have yet to be identified. Here, we take advantage of big data efforts to compile plant species occurrence and trait data to analyse the spatial patterns of assemblage means and variances...
Plant community structure and nitrogen inputs modulate the climate signal on leaf traitsNARA Subscribed
Aim Leaf traits strongly impact biogeochemical cycles in terrestrial ecosystems. Understanding leaf trait variation along environmental gradients is thus essential to improve the representation of vegetation in Earth system models. Our aims were to quantify relationships between leaf traits and climate in permanent grasslands at a biogeographical scale and to test whether these relationships were sensitive to (a) the level of...
TRY – a global database of plant traitsNARA Subscribed
Plant traits – the morphological, anatomical, physiological, biochemical and phenological characteristics of plants and their organs – determine how primary producers respond to environmental factors, affect other trophic levels, influence ecosystem processes and services and provide a link from species richness to ecosystem functional diversity. Trait data thus represent the raw material for a wide range of research from evol...
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