Rationale Chronic stress, frequently associated with dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis and reduced neuroplasticity, is a major risk factor for psychiatric disorders such as anxiety and depression. Objective The present study aimed to validate a 21-day chronic unpredictable stress (CUS) model and to investigate the effects of the Mas receptor agonist AVE0991 on stress-induced behavioral and molecular...

Mercury (Hg²⁺) contamination poses a significant threat to environmental and human health, necessitating the development of sensitive and selective detection methods. In this study, we report the design and application of a novel quinoline-based chemosensor, HMQC, for the detection of Hg²⁺ in aqueous environments. The probe exhibits dual fluorescence behavior, with quenching at acidic pH (pH 5) and enhancement at neutral pH (p...

Stress is defined as a disruption of homeostasis that elicits adaptive responses aimed at restoring physiological balance. However, when stress becomes chronic or overwhelming, maladaptive changes may occur, contributing to endocrine, behavioral, and neuropsychiatric dysfunctions. Beyond the classical neuroendocrine axes, such as the sympatho-adrenomedullary and hypothalamic–pituitary–adrenal (HPA) axes, the renin-angiotensin...