M. Bailey results 416
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The sustained rise of antibiotics resistance demands the discovery of novel compounds to enhance current treatment efficiency and decrease the spread of resistant pathogens. Gloeophyllum trabeum is a common wood-decaying basidiomycete fungus, however its capability for production of specialised metabolites remains poorly understood. We integrated spectroscopic analysis, computational genomic, and molecular docking to explore i...
The host’s ability to clear parasites (resistance) and their capacity to reduce the impact of a given parasite burden (tolerance) is often described under conditions of a single pathogen challenge. We developed a mouse infection model to investigate the impact of co-infection on host resistance and tolerance to Heligmosomoides bakeri . C57BL/6 mice were infected with the helminth parasite H. bakeri and Theiler’s murine encepha...
Heterogeneity in the association between APOE ε4 carrier status and dementia risk by modifiable and non-modifiable risk factorsNARA Subscribed
Dementia is a major public health challenge, and Apolipoprotein E ( APOE ) ε4 is strongly associated with all-cause dementia, particularly Alzheimer’s disease (AD). We aim to quantify the overall contribution of modifiable lifestyle, adiposity, socioeconomic status (SES), and health conditions occurring before dementia, to the association between ε4 genotype and the development of all-cause dementia, with AD examined as a majo...
Temperate and filamentous bacteriophages as reservoirs of bacterial virulence in stony coral tissue loss diseaseNARA Subscribed
Lysogenic conversion, in which bacteriophages (viruses that infect bacteria) integrate into bacterial genomes and confer new phenotypic traits on their hosts, is a well-established mechanism for the emergence of pathogens. While this process underpins many bacterial diseases in humans and other animals, its role in coral disease remains largely unexplored. Here, we investigate the potential role of lysogenic conversion in ston...
Watershed land cover predicts the abundance of macroplastic and other anthropogenic litter in streamsNARA Subscribed
Macroplastic and other types of macroscopic anthropogenic litter (AL; trash, particles > 5 mm) are pervasive across ecosystems, persistent in the environment, increasing in abundance, and can degrade into microplastics (particles 2 and 0.011–87.482 g/m 2 . Watershed impervious surface area and urban cover were significant predictors of AL by count (pseudo R 2 = 0.418), likely due to greater numbers of AL sources and enhanced c...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
At least 10 minutes of seated rest is required for stabilisation of blood-based hydration biomarkersNARA Subscribed
Postural changes elicit well-described haemodynamic effects on plasma volume, affecting blood-based hydration variables. While the time required for plasma volume stabilisation is well-established for supine rest, less is known for blood samples collected in a seated position, as is commonplace in physiology and nutrition experiments. Seventeen healthy participants (9 males; 8 females) stood stationary for 20 min in an upright...
Success of restoration strategies in preventing extirpation of 2 critically endangered coral speciesNARA Subscribed
An unprecedented marine heatwave in 2023 caused widespread coral bleaching and mortality throughout the Caribbean. In the Florida Keys (USA), 2 foundation species, elkhorn coral ( Acropora palmata ) and staghorn coral ( Acropora cervicornis ), were severely affected. These species have been the primary focus of reef restoration in Florida for decades. Substantial losses of these species occurred in outplanted populations, in o...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...