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Relationship of temperature with declines and persistence of Myotis lucifugus after white‐nose syndromeNARA Subscribed
White‐nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans (Pd), ranks among the most devastating wildlife diseases in recent history and is driving severe declines in North American bats. Identifying environmental factors that influence both the severity of population crashes and the potential for population persistence is essential for effective mitigation. We used a long‐term dataset from hibernacula acros...
Additively Manufactured Partially Porous PAEK Topologies for Proximal Tibia Revision Cones and SleevesNARA Subscribed
Metaphyseal cones and sleeves are an increasingly common component utilized in revision total knee arthroplasty. These partially porous devices have a high surface area and aim to integrate with cancellous bone of the distal femur and proximal tibia to increase the stability of the implant. Incidences of metal-hypersensitivity and macrophage-stimulated osteolysis have motivated the development of a non-metal alternative in the...
Anthropogenic debris accumulation in the Argentine deep sea: evidence of an irreversible sinkOA Marine
The seafloor is recognized as a major sink for marine debris, while deep-sea litter remains poorly investigated due to the logistical and economic constraints associated with seabed exploration. This study reports for the first time the occurrence of marine debris found on the Argentine deep seafloor using the SOI’s Remotely Operated Vehicle (ROV), providing the first documented evidence for this region. A total of 29 litter i...
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
Soil fauna regulates litter decomposition and soil organic matter transformation, acting as both litter and microbial feeders. Whether these feeding modes shift along environmental gradients remains unclear. We tested if microbivory increases with decreasing litter quality and in colder climates, both factors limiting detritus digestion by fauna. Using stable isotope composition (δ 13 C, δ 15 N) of 7408 soil invertebrate sampl...
Transition to fetal calf serum-free culture enhances kidney proximal tubule cell bioenergetics and allows pharmacological applicationsNARA Subscribed
Proximal tubule in vitro systems are important tools in pre-clinical drug development, providing insights into drug disposition and safety. Cells are often cultured in medium containing fetal calf serum (FCS); however, FCS addition is not physiologically relevant for cells of human origin. Here, in vitro cultures of human kidney proximal tubule cells were transitioned to FCS-free medium. The impact of FCS-free medium on matura...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
In several studies of chromite-rich cumulates in layered intrusions, the Cr/Al ratio of chromite varies significantly within centimetre-to-decimetre scale layering. In the G-H chromitite section of the Stillwater Complex (United States), Cr/Al ratios are consistently higher, by up to relative 20%, in the most chromite-rich rocks compared with immediately adjacent layers. Systematic relationships between Cr/Al ratios and chromi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer’s disease in African AmericansNARA Subscribed
Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a large number of susceptibility genes, but most of AD heritability remains unexplained, implying the existence of additional genes. Furthermore, the majority of the GWAS have been conducted in people of European descent, and the genes important for AD susceptibility in people of African descent have been underexplored. In this hypothesis-genera...
Shipboard ballast water management systems (BWMS) commonly employ chlorine or other oxidants to treat ballast. Oxidant-based BWMS inject these biocides to meet a concentration threshold or target value that is lethal to most aquatic organisms. Resulting concentrations of total residual oxidant (TRO) may span two orders of magnitude between initial doses (e.g., ~10 mg L−1) and discharged ballast, which must meet discharge limit...