M. Beckmann results 42
· Newest (Page 1/2, per page 25)
Author: M. Beckmann ×Clear All Filters
Search Results
Realigning structural MR images to stereotactic AC-PC space is a standard procedure that enhances anatomical consistency both within and across neuroimaging studies, allowing for precise spatial localization and reliable cross-subject comparisons in both clinical and research contexts. However, different versions of AC-PC spaces, stemming from varying definitions of the AC-PC axis as outlined in common stereotactic atlases lik...
Improving the use of expert opinion in disease risk analysis for conservation translocationsNARA Subscribed
Conservation translocations are subject to considerable uncertainty and risk, of which disease is one of the most recognized. To address disease risks, several protocols for qualitative disease risk analysis (qDRA) exist and are used for responsible conservation translocation planning. Existing qDRA protocols usually rely on expert judgment, but they lack quantitative aggregation of elicited estimates, transparent treatment of...
Formation and persistence of estragole-derived DNA adducts in human liver cells and tissueNARA Subscribed
Estragole (ES) is a phenylpropene naturally occurring in various herbs and spices, such as fennel and basil. Humans are exposed to ES via the diet or herbal medicinal products. Following its gastrointestinal resorption, hepatic bioactivation of ES by Cytochrome P450 monooxygenases (CYPs) and sulfotransferases (SULTs) can lead to DNA adduct formation and liver cancer in rodents. Up to now, no data is available on ES-dependent D...
Characterizing functional connectivity gradients for the hippocampus–amygdala complex in healthy and psychiatric cohortsNARA Subscribed
The hippocampus and amygdala play essential roles in human cognition and emotion, through their extensive connectivity with other brain regions and close interaction between them. Uncovering the functional organization of the hippocampus–amygdala complex and its relationship with neurotransmitter distribution can enhance our understanding of their biological functionality, and provide a basis for further exploration of the cli...
TRPM6 in murine kidneys—of targets and antibodiesNARA Subscribed
Magnesium is the fourth most abundant cation in the human organism. As a key-player in many enzymatic reactions, magnesium homeostasis disbalance can cause severe disorders. In the early 2000s, the transient receptor potential melastatin channel 6 (TRPM6) was identified as a critical protein in renal Mg 2+ -reabsorption in the distal convoluted tubule (DCT). As the key-interface responsible for salt/water adaptation to environ...
Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in SheepNARA Subscribed
Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-SBI coincides with cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association and convincing pathophysiological concepts suggest that CSF-Hb could be a targetable trigger of SBI. However, spar...
Functional and vascular neuroimaging in maritime pilots with long-term sleep disruptionNARA Subscribed
The mechanism underlying the possible causal association between long-term sleep disruption and Alzheimer’s disease remains unclear Musiek et al. 2015. A hypothesised pathway through increased brain amyloid load was not confirmed in previous work in our cohort of maritime pilots with long-term work-related sleep disruption Thomas et al. Alzheimer’s Res Ther 2020;12:101. Here, using functional MRI, T2-FLAIR, and arterial spin l...
Sperm whales exhibit variation in echolocation tactics with depth and sea state but not naval sonar exposuresNARA Subscribed
Auditory masking by anthropogenic noise may impact marine mammals relying on sound for important life functions, including echolocation. Animals have evolved antimasking strategies, but they may not be completely effective or cost‐free. We formulated seven a priori hypotheses on how odontocete echolocation behavior could indicate masking. We addressed six of them using data from 15 tagged sperm whales subject to experimental e...
Systemweite Anreicherung von RNA-Protein-KomplexenNARA Subscribed
RNA-protein complexes (RNPs) are key players in cell physiology, especially in the context of RNA metabolism. However, their analysis has been dependent on specific protein epitopes or RNA sequence elements, preventing unbiased and cell-wide studies. We developed a three-step protocol, termed Phenol Toluol extraction (PTex), to isolate the complete suite of RNPs in cells, solely based on their unique physicochemical properties...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Plasticity in elk migration timing is a response to changing environmental conditionsNARA Subscribed
Migration is an effective behavioral strategy for prolonging access to seasonal resources and may be a resilient strategy for ungulates experiencing changing climatic conditions. In the Greater Yellowstone Ecosystem ( GYE ), elk are the primary ungulate, with approximately 20,000 individuals migrating to exploit seasonal gradients in forage while also avoiding energetically costly snow conditions. How climate‐induced changes i...