Purpose AlzeCure Pharma AB is developing novel positive allosteric modulators of Trk-receptors for treatment of Alzheimer’s disease, depression, other psychiatric conditions and other disorders where cognition is impaired. The preceding candidate drug ACD855 was shown to have a too long half-life in humans to allow further development. To de-risk the development of the follow-up compound ACD856, the oral single ascending dose...

In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS) glycosaminoglycans are deemed essential to the glomerular filtration barrier, including the glomerular endothelial glycocalyx. Animal studies have shown that loss of HS results i...

Human disturbances such as angling and manual handling may have long‐term effects on the behaviour of pike, E sox lucius L ., an ecologically important species. Using continuous high‐resolution positional telemetry, this study compared the swimming activity of handled and unhandled pike in a small lake. Pike pre‐equipped with acoustic transmitters were angled and exposed to a handling protocol including measurements of length...

Pike Esox lucius in the absence of prey and conspecifics were shown to have the highest habitat‐change activity during dusk and to decrease preference for complex habitats in turbid water. As the behaviours indicate routine responses in the absence of behavioural interactions, E. lucius spatio‐temporal distributions should be directly affected and thereby more easily assessed and avoided by prey, with potential consequences fo...