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Key message Quantitative mass spectrometry of Arabidopsis telomerase uncovered AtLa1, a homolog of ciliate and yeast proteins that promotes telomerase maturation. AtLa1 is essential for telomerase function in vivo, and in vitro it engages the same region of AtTR bound by AtNAP57, homologous to a telomerase accessory from mammals. Abstract Striking divergence is evident in the biogenesis pathways and protein complements of telo...
Aim To assess phylogeographic structure, phylogenetic diversity and historical diversification processes in ammotrechid camel spiders from the Baja California Peninsula. Location Baja California Sur, Mexico. Time Period Miocene to Pleistocene. Major Taxa Studied Ammotrechid camel spiders (Solifugae: Ammotrechidae). Methods We conducted the first phylogeographic analysis of Baja California Sur ammotrechid camel spiders using mi...
Confirmed Outbreaks of Streptococcosis Caused by Streptococcus agalactiae Serotype Ia in Nile Tilapia Culture From Campeche, MexicoNARA Subscribed
Streptococcus agalactiae was confirmed as the etiologic agent of streptococcosis in Nile tilapia ( Oreochromis niloticus ) from Campeche, Mexico, during a cross‐sectional investigation of eight semi‐intensive farms (2021–2022) that yielded virulent strains in a challenge assay. Standard bacteriology, histopathology, API‐20 Strep phenotyping, one‐step PCR, and real‐time PCR confirmed S. agalactiae in five farms (62.5%). Gross a...
The future of how we understand and manage ecosystems largely depends on direct and continuous observations that connect local territories to planetary processes. Latin America (LATAM: Mexico, Central and South America, and the Caribbean) hosts ecosystems critical for regulating global carbon, water, and energy cycles. However, persistent underinvestment in science and technology hampers the long‐term monitoring capacity neede...
Carpobrotus taxa benefit more from clonal integration in their non-native than native rangesNARA Subscribed
Understanding physiological integration in invasive clonal plants is relevant to invasion biology because resource transfer across ramets may allow alien plants to buffer spatial heterogeneity in their introduced areas. However, experimental evidence across native and non-native ranges is limited. Here, we tested whether physiological integration provides greater performance benefits to Carpobrotus taxa in non-native than nati...
Vaccine strategies for cancer prevention in Lynch syndrome: the potential of dendritic cell-based therapyNARA Subscribed
Cancer vaccines offer a promising strategy for cancer prevention, particularly in hereditary cancer syndromes such as Lynch syndrome (LS). LS is characterized by a high lifetime risk of developing various malignancies due to defects in DNA mismatch repair, leading to an accumulation of mutations, particularly frameshift insertion/deletions (indels) within microsatellite loci. These indels create shared tumour-specific neoantig...
Cytotoxic edema (CE) is a radiographic marker of early tissue injury in cerebral venous thrombosis (CVT) associated with poor outcomes, yet its mechanistic pathway remains unclear. We investigated whether intraparenchymal hemorrhage (IPH) mediates the association between CE and outcomes. We conducted a retrospective cohort study using the multicenter CLOT-VENUS registry, including acute CVT patients treated at two Comprehensiv...
Main conclusion Virus-like particles (VLP) from hepatitis C virus were successfully produced in Nicotiana benthamiana plants for the first time, by co-expressing three viral proteins (Core, E1 and E2) in a polycistron-like arrangement. Abstract Hepatitis C virus (HCV) remains a global health challenge, underscoring the need for a preventive vaccine. Virus-like particles (VLP) offer a safe alternative, as they resemble native v...