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The immunogenic potential of AZD1402 (Elarekibep) T-cell epitopes in healthy volunteers and drug-exposed clinical trial participantsNARA Subscribed
AZD1402 (Elarekibep) is a novel anticalin with engineered IL-4Rα antagonist binding properties that was under development for inhaled treatment of asthma. Structural similarity to tear-lipocalin is thought to limit immunogenicity risk; however, a range of treatment-emergent hypersensitivity-like adverse events were observed in a clinical study. This study aimed to (i) explore the activation of drug-exposed human T-cells with A...
Using stable isotopes to describe the trophic structure of gelatinous zooplankton across the deep pelagicNARA Subscribed
Although gelatinous zooplankton are key members of marine ecosystems and food webs, their trophic ecology is poorly described across the deep pelagic. We used stable carbon (bulk tissue) and nitrogen (bulk tissue and amino acid) isotope analysis to estimate the trophic positions (TPs) of abundant gelatinous zooplankton (chaetognaths, cnidarians, ctenophores, mollusks, pelagic tunicates) across depth habitats. We collected gela...
Private gardens comprise a large component of greenspace in cities and can offer substantial conservation opportunities. There has been strong advocacy from researchers, policymakers, and conservation practitioners to engage householders in wildlife-friendly gardening practices to increase the quantity, quality and connection of habitat resources for urban wildlife. Despite this call to action, there remains limited knowledge...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Recruitment and growth of two small‐bodied resident fish species (Gobiidae and Atherinidae) in oligohaline, seasonally open lagoonsNARA Subscribed
Spatio‐temporal recruitment patterns, growth and survival of the Swan River goby Pseudogobius olorum and western hardyhead Leptatherina wallacei are described from two small, coastal lagoons on the south coast of Western Australia. In these lagoons, estuarine salinity dynamics were relatively stable over much of the autumn–spring period when freshwater inputs from rivers were reduced and there was no oceanic connection. Prefle...
Diversity of hopanoids and squalene‐hopene cyclases across a tropical land‐sea gradientNARA Subscribed
Summary Bacterial hopanoids are ubiquitous in Earth surface environments. They hold promise as environmental and ecological biomarkers, if the phylogeny and physiological drivers of hopanoid biosynthesis can be linked with the distribution of hopanoids observed across a breadth of samples. Here we survey the diversity of hopanoid cyclases from a land‐sea gradient across the island of San Salvador, in the easternmost part of th...