M. Cox results 293
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Purpose Many abdominal aortic aneurysm (AAA) patients develop intraluminal thrombus (ILT), but the role of ILT in AAA progression and rupture is poorly understood. Methods To evaluate ILT in AAAs, we induced AAAs in C57Bl6/J mice via surgical application of topical elastase to the abdominal aorta below the renal arteries and administration of β-aminopropionitrile (BAPN) in drinking water. Ultrasound images of these AAAs were c...
Stomatal Decoupling From Photosynthesis Under High Temperatures Is Consistent With Stomatal OptimisationNARA Subscribed
Stomatal pores on plant leaves regulate the gain of carbon through photosynthesis and the loss of water through transpiration. Through their responses to environmental conditions, stomata can constrain plant productivity and transpiration fluxes, exerting a strong control on climate feedbacks over land. Although mechanistic modelling of stomata remains a challenge, semi‐empirical and optimisation models have been successfully...
Animals maintain close associations with diverse microbiota that inhabit their digestive tracts, and these associations can profoundly affect host physiology and fitness. Gut microbiome composition is shaped by both host traits and environmental factors, yet the relative importance of these forces remains unclear in many taxa, including squamate reptiles (lizards and snakes). To address this gap, we analysed the gut microbiome...
Success of restoration strategies in preventing extirpation of 2 critically endangered coral speciesNARA Subscribed
An unprecedented marine heatwave in 2023 caused widespread coral bleaching and mortality throughout the Caribbean. In the Florida Keys (USA), 2 foundation species, elkhorn coral ( Acropora palmata ) and staghorn coral ( Acropora cervicornis ), were severely affected. These species have been the primary focus of reef restoration in Florida for decades. Substantial losses of these species occurred in outplanted populations, in o...
Changes in Key Biodiversity Area networks following national comprehensive assessmentsNARA Subscribed
Key Biodiversity Areas (KBAs) are sites of significance for the global persistence of biodiversity. Based on the Global Standard for the Identification of Key Biodiversity Areas (KBA Standard), published in 2016, sites are currently being assessed for KBA designation in a growing number of countries across the world. For these assessments, the KBA criteria are applied to all species and ecosystems with available data. We revie...
Inter-individual variability of neurotransmitter receptor and transporter density in the human brainNARA Subscribed
Neurotransmitter receptors guide the propagation of signals between brain regions. Mapping receptor distributions in the brain is therefore necessary for understanding how neurotransmitter systems mediate the link between brain structure and function. Normative receptor density can be estimated using group averages from Positron Emission Tomography (PET) imaging. However, the generalizability and reliability of group-average r...
DEK Loss Induces Task-specific Deficits in Learning and Memory and Reprograms the Hippocampal Transcriptome in MiceNARA Subscribed
DEK is an estrogen-responsive chromatin-remodeling protein broadly expressed in the murine and human brain, with high expression in memory-relevant regions such as the hippocampus. Prior work from our group and others has linked DEK loss to cellular features associated with Alzheimer’s disease and Alzheimer’s disease-related dementias. Notably, our group has demonstrated that DEK expression declines with increasing dementia se...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
NCBI Orthologs: Public Resource and Scalable Method for Computing High-Precision Orthologs Across Eukaryotic GenomesNARA Subscribed
Orthologs are fundamental for enabling comparative genomics analyses that further our understanding of eukaryotic biology. The unprecedented increase in the availability of high-quality eukaryotic genomes necessitates scalable and accurate methods for orthology inference. The National Center for Biotechnology Information (NCBI) developed “NCBI Orthologs”, a resource and a computational pipeline designed to meet this challenge...
Consumer‐mediated nutrient dynamics (CND), through which animals' metabolic waste products fertilize primary producers, drive variability in nutrient availability in tropical waters. This variability influences primary productivity and community functioning. Yet, examinations of CND as a driver of nutrient variability in temperate marine ecosystems are limited. Therefore, we assessed the existence and drivers of variation in C...
The biogenic structure of foundation species provides critical habitat for coastal marine taxa. In temperate ecosystems, forests of large, canopy‐forming macroalgae ( Macrocystis pyrifera , Nereocystis luetkeana ) support rich communities of fishes and macroinvertebrates. However, it is unclear how the biological assemblages of kelp forests vary with respect to the dominant canopy‐forming species, structural attributes of the...
The population of pillar coral, Dendrogyra cylindrus , in Florida was decimated from 2013 to 2020, primarily by the emergence of stony coral tissue loss disease (SCTLD). Monitoring of survivors from 2021 to early 2025 showed that the population underwent an additional 96% decline in live tissue, a 78% loss in living colonies, and a 55% loss of genotypes. SCTLD continued to be the primary cause of these losses. Although some su...