M. Cross results 110
· Newest (Page 1/5, per page 25)
Author: M. Cross ×Clear All Filters
Search Results
The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosaminesNARA Subscribed
N -nitrosamine (NA) impurities in pharmaceuticals represent “cohort of concern” compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation. Increasing interest in mammalian cell-based genotoxicity/mutagenicity assays prompted our assessment of the in vitro alkaline comet assay regarding its predictive power for NAs. Here, precision-cut liver slices (...
Ecological theory predicts that consumers should be co‐limited by resource quantity and quality, given widespread consumer‐resource nutritional imbalances. We used 25 estimates of annual community secondary production (ACSP) of stream macroinvertebrates to assess the relative roles of basal resource quantity (leaf litter standing stock [LLSS]) and quality (% nitrogen and % phosphorus of leaf litter) in modulating patterns of p...
Environmental warming increases the importance of high‐turnover energy channels in stream food websNARA Subscribed
Warming temperatures are altering communities and trophic networks across Earth's ecosystems. While the overall influence of warming on food webs is often context‐dependent, increasing temperatures are predicted to change communities in two fundamental ways: (1) by reducing average body size and (2) by increasing individual metabolic rates. These warming‐induced changes have the potential to influence the distribution of food...
Comparing environmental impacts of deep‐seabed and land‐based mining: A defensible frameworkNARA Subscribed
The crises of climate change and biodiversity loss are interlinked and must be addressed jointly. A proposed solution for reducing reliance on fossil fuels, and thus mitigating climate change, is the transition from conventional combustion‐engine to electric vehicles. This transition currently requires additional mineral resources, such as nickel and cobalt used in car batteries, presently obtained from land‐based mines. Most...
Purpose The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used t...
Defining an epidemiological landscape that connects movement ecology to pathogen transmission and pace‐of‐lifeNARA Subscribed
Pathogen transmission depends on host density, mobility and contact. These components emerge from host and pathogen movements that themselves arise through interactions with the surrounding environment. The environment, the emergent host and pathogen movements, and the subsequent patterns of density, mobility and contact form an ‘epidemiological landscape’ connecting the environment to specific locations where transmissions oc...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Body size and digestive system shape resource selection by ungulates: A cross‐taxa test of the forage maturation hypothesisNARA Subscribed
The forage maturation hypothesis (FMH) states that energy intake for ungulates is maximised when forage biomass is at intermediate levels. Nevertheless, metabolic allometry and different digestive systems suggest that resource selection should vary across ungulate species. By combining GPS relocations with remotely sensed data on forage characteristics and surface water, we quantified the effect of body size and digestive syst...
More high-quality, in situ observations of essential marine variables are needed over the seasonal ice zone to better understand Arctic (or Antarctic) weather, climate, and ecosystems. To better assess the potential for arrays of uncrewed surface vehicles (USVs) to provide such observations, five wind-driven and solar-powered saildrones were sailed into the Chukchi and Beaufort Seas following the 2019 seasonal retreat of sea i...