M. Curran results 101
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A primary care pharmacogenetic precision medicine pilot based on specific Māori tribal ethical frameworks and principlesNARA Subscribed
Indigenous tribal communities are frequently underserved by genomic medicine because they are under-represented in research, often live in remote locations and have ethical and cultural perspectives that vary from westernised standpoints. The Rakeiora platform, a permissioning and analytical environment that incorporates Māori perspectives and ethical frameworks on how precision medicine research is best conducted was used to...
Guideline-concordance along the cancer care continuum and breast cancer mortality by race and ethnicity: a SEER-Medicare studyNARA Subscribed
Purpose To examine the relationship between guideline-concordant breast cancer care and hazard of cancer death by patient race and ethnicity. Methods We used SEER-Medicare data to identify 212,555 older women diagnosed with invasive breast cancer between 2000 and 2017. Guideline-concordant diagnostic workup, locoregional treatment, and initiation of systemic therapy were defined using NCCN guidelines. Hazards of breast cancer...
Soil Plant Growth‐Promoting Bacterial Diversity Changes With Land Use Intensity and Environmental ConditionsNARA Subscribed
Aim Plant growth‐promoting bacteria (PGPB) play crucial roles in supporting plant growth and, therefore, in undisturbed ecosystems and agricultural systems. We aimed to understand how these microbial communities change under different land use and environmental conditions. This is an important prerequisite to utilising the positive impact PGPB may have for sustainable food production. Location 537 sites across Aotearoa New Zea...
Leaf Dry Matter Content Is Phylogenetically Conserved and Related to Environmental Conditions, Especially Wildfire ActivityNARA Subscribed
Leaf dry matter content (LDMC) is an important determinant of plant flammability. Investigating global patterns of LDMC could provide insights into worldwide plant flammability patterns, informing wildfire management. We characterised global patterns of LDMC across 4074 species from 216 families, revealing that phylogenetic and environmental constraints influence LDMC. LDMC varied across growth forms and taxonomic groups, disp...
Floods are amongst the most frequent disasters in terms of human and economic impacts. This study provides new insights into the frequency of loss of life at the global scale, mortality fractions of the population exposed to floods, and underlying trends. A dataset is compiled based on the EM-DAT disaster database covering the period 1975 until 2022, extending previous studies on this topic. Flood impact data are analysed over...
Damage to tropical forests caused by cyclones is driven by wind speed but mediated by topographical exposure and tree characteristicsNARA Subscribed
Each year, an average of 45 tropical cyclones affect coastal areas and potentially impact forests. The proportion of the most intense cyclones has increased over the past four decades and is predicted to continue to do so. Yet, it remains uncertain how topographical exposure and tree characteristics can mediate the damage caused by increasing wind speed. Here, we compiled empirical data on the damage caused by 11 cyclones occu...
Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activationNARA Subscribed
Molecular homeostats play essential roles across all levels of biological organization to ensure a return to normal function after responding to abnormal internal and environmental events. SKN-1 is an evolutionarily conserved cytoprotective transcription factor that is integral for the maintenance of cellular homeostasis upon exposure to a variety of stress conditions. Despite the essentiality of turning on SKN-1/NRF2 in respo...
Humanizing marine spatial planning: A salutogenic approachNARA Subscribed
Atlantic mackerel or Amalamaq ( Scomber scombrus ) has been subject to diverse fishing pressures in Atlantic Canada for commercial, bait, recreational, and Indigenous food-social-ceremonial (FSC) fisheries, resulting in its substantial social and cultural significance in the region. Recent stock declines have led to closures of the commercial and bait mackerel fisheries, while recreational and FSC harvesters retain respectivel...
Monitoring how populations respond to sustained conservation measures is essential to detect changes in their population status and determine the effectiveness of any interventions. In the case of sea turtles, their populations are difficult to assess because of their complicated life histories. Ground-derived clutch counts are most often used as an index of population size for sea turtles; however, data are often incomplete w...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Background Preclinical and human studies suggest that adolescent cannabis use may be associated with worse cognitive outcomes than adult cannabis use. We investigated the associations between chronic cannabis use and cognitive function in adolescent and adult cannabis users and controls. We hypothesised user-status would be negatively associated with cognitive function and this relationship would be stronger in adolescents tha...
The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging studyNARA Subscribed
Rationale There is growing interest in the therapeutic potential of cannabidiol (CBD) across a range of psychiatric disorders. CBD has been found to reduce anxiety during experimentally induced stress in anxious individuals and healthy controls. However, the mechanisms underlying the putative anxiolytic effects of CBD are unknown. Objectives We sought to investigate the behavioural and neural effects of a single dose of CBD vs...
Reliable hazard analysis is crucial in the flood risk management of river basins. For the floodplains of large, developed rivers, flood hazard analysis often needs to account for the complex hydrology of multiple tributaries and the potential failure of dikes. Estimating this hazard using deterministic methods ignores two major aspects of large-scale risk analysis: the spatial–temporal variability of extreme events caused by t...
Many animal signals are brightly colored and convey information about species identity as well as information about individual conspecifics. Colorful bird and lizard signals have received much attention, and many studies have related specific spectral properties of these signals to variation in mating success and territory defense. Far less attention has been given to invertebrates even though there are spectacularly colorful...