Introduction The distal interphalangeal joint (DIPJ) plays a crucial role in the function of the hoof and digit. Dislocations and subluxations in this region are rare and primarily of traumatic origin. Case Report This case report aims to describe two unusual cases of open DIPJ dislocation, including clinical presentation, diagnostic workup, treatment, and long-term follow-up. Both animals presented with open traumatic distal...

Rays of the family Rhinopteridae Jordan & Evermann, 1896 are highly migratory and widely distributed in warm tropical and temperate waters. Along the Brazilian coast, the presence of two species has been recorded: Rhinoptera bonasus Mitchill, 1815 and Rhinoptera brasiliensis Müller, 1836. These stingrays are commonly caught as bycatch in trawl fisheries, however, the two species lack distinctive external morphological features...

Cytokines are small glycosylated polypeptides that orchestrate immune responses and are widely produced in recombinant form for therapeutic and research purposes. This review highlights Komagataella phaffii as an efficient host for the heterologous expression of recombinant cytokines from human and other species. A systematic search of PubMed, Scopus, and Web of Science identified studies addressing upstream and downstream pro...

Background Dysregulation of the innate immune response to SARS-CoV-2 has been linked to poor outcomes in COVID-19. Neutrophils are key players in this response, displaying distinct functional profiles associated with disease severity. This study investigates how neutrophil phenotypes, and their mediators are modulated in severe COVID-19 following vaccination. Methods and Results We conducted an observational case-control study...

Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...

Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort usi...

Urban wastewater systems represent important interfaces between human activity and the environmental occurrence of antimicrobial resistance (AMR) markers. We assessed the temporal dynamics of intI1 , ermB , and the 16 S rRNA gene by quantitative PCR across three wastewater systems (EPC, CJC, and JW) in Fortaleza, Brazil, from November 2021 to November 2023. Bacterial communities were additionally characterized by 16 S rRNA gen...

This study investigated the identification, antimicrobial resistance patterns, and phenotypic and genotypic traits of 30 Klebsiella isolates recovered from diverse animal species and infection sites. MALDI-TOF MS demonstrated higher accuracy in species-level identification than conventional phenotypic approaches, revealing a predominance of Klebsiella pneumoniae (80%), followed by K. variicola , K. aerogenes , and K. oxytoca ....

The pursuit of sustainable and efficient animal production systems has intensified global interest in microbiota-targeted nutritional strategies. This review synthesizes current research on prebiotics and probiotics, selectively utilized microbial substrates and beneficial live microorganisms, respectively, that confer health benefits, across major livestock and aquaculture sectors, including poultry, swine, ruminants, fish, a...