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Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissuesNARA Subscribed
Within the bovine immune response, a distinct type of immunoglobulin (Ig), known as ultralong complementarity-determining region 3 (CDR3) antibodies, coexists alongside canonical Igs. These ultralong heavy chains (HC) feature a remarkable structure with a lengthened CDR3 of the heavy chain (CDR H3), allowing them to adopt either a smaller and more extended paratope than canonical antibodies. However, very little is known about...
Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscleNARA Subscribed
Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves muscle size and function; however, the response to exercise training is variable in older adults. The objective of our study was to determine both the age-independent and age-dependent changes to the transcriptome following progressive resistance exercise training. Skeletal muscle biopsies were obtained bef...
Aim To examine the species richness, distribution and macroecological patterns of elasmobranch assemblages across a broad latitudinal gradient in the Eastern Pacific Ocean (EPO). Location The study area encompasses the Pacific coast of the American continent, spanning from 65°N to 60°S, and extending from the coastline to approximately 1000 km offshore, encompassing the oceanic archipelagos. Taxon Elasmobranchs. Methods Utilis...
Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical reviewNARA Subscribed
Immunotherapy is a rapidly evolving field, with many models attempting to describe its impact on the immune system, especially when paired with radiotherapy. Tumor response to this combination involves a complex spatiotemporal dynamic which makes either clinical or pre-clinical in vivo investigation across the resulting extensive solution space extremely difficult. In this review, several in silico models of the interaction be...
Homosalate (HMS) is a UV filter used in sunscreens and personal care products as a mixture of cis - and trans -isomers. Systemic absorption after sunscreen use has been demonstrated in humans, and concerns have been raised about possible endocrine activity of HMS, making a general population exposure assessment desirable. In a previous study, it was shown that the oral bioavailability of cis -HMS ( c HMS) is lower than that of...
Installations of artificial structures in coastal oceans create de facto habitat for marine life. These structures encompass wide varieties of physical characteristics, reflecting their multiple, diverse purposes and creating a need to understand which characteristics maximize fish habitat. Here, we test how physical characteristics – horizontal area, vertical relief, and spatial isolation – relate to fish density from echosou...
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging are not well understood. To better understand mechanisms of muscle aging, we investigated the potential role of ATF4, a transcription regulatory protein that can rapidly promote skeletal muscle atrophy in young animals deprived of adequate nutrition or a...
Combined synoptic and regional weather patterns affecting atmospheric Poaceae pollen concentrations in Sydney, AustraliaNARA Subscribed
Inhalation of grass pollen can result in acute exacerbation of asthma, prompting questions about how grass pollen reaches metropolitan areas. We establish typical atmospheric Poaceae (grass) pollen concentrations recorded at two pollen samplers within the Sydney basin in eastern Australia and analyse their correlation with each other and meteorological variables. We determine the effect of synoptic and regional airflow on Poac...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The history of elasmobranch ageing highlights the difficulty of age estimation in animals lacking ossified structures. Ageing techniques are numerous, yet all are limited by difficulties of validation and verification and inherent subjectivity. Sample scarcity further hinders progress as limited samples cannot be risked on exploratory techniques. This study explored the use of genetic analysis of telomeres as a method of age d...
Ghost sharks (subclass Holocephali) remain a largely data‐poor group of cartilaginous fishes. The general paucity of attention may partially be related to identification and unresolved taxonomic issues, occurrence in the deep oceans, and their low value and interest in fisheries (which some notable exceptions). Here, we synthesize and assess the extinction risk of all known extant ghost sharks (52 species) by applying the IUCN...
DeepSurvNet: deep survival convolutional network for brain cancer survival rate classification based on histopathological imagesNARA Subscribed
Histopathological whole slide images of haematoxylin and eosin (H&E)-stained biopsies contain valuable information with relation to cancer disease and its clinical outcomes. Still, there are no highly accurate automated methods to correlate histolopathological images with brain cancer patients’ survival, which can help in scheduling patients therapeutic treatment and allocate time for preclinical studies to guide personalized...