M. Finkelstein results 25
· Newest (Page 1/1, per page 25)
Author: M. Finkelstein ×Clear All Filters
Search Results
Gut dysfunction commonly precedes motor symptoms in Parkinson’s disease (PD), but the mechanistic sequence of gut versus brain pathology remains unclear. This work aimed to define the timing of intestinal barrier dysfunction relative to central nervous system (CNS) changes in the A53T α-synuclein transgenic mouse model of PD. Functional and molecular assessments of the gastrointestinal tract (ileum and colon) were conducted at...
Brain Delivery of a Kv1.3-Blocking Peptide is not Enhanced by Conjugation to Blood–Brain Barrier Shuttle PeptidesNARA Subscribed
Purpose The voltage-gated potassium channel K V 1.3 is upregulated on pro-inflammatory microglia, and its blockade is effective in reducing neuroinflammation in vitro and in vivo. The most potent and selective K V 1.3 blockers identified to date are disulfide-rich, venom-derived peptides, which are largely excluded from the brain by the blood–brain barrier (BBB). As BBB shuttle peptides have been reported to promote receptor-m...
Practical Guide to Measuring Wetland Carbon Pools and FluxesNARA Subscribed
Wetlands cover a small portion of the world, but have disproportionate influence on global carbon (C) sequestration, carbon dioxide and methane emissions, and aquatic C fluxes. However, the underlying biogeochemical processes that affect wetland C pools and fluxes are complex and dynamic, making measurements of wetland C challenging. Over decades of research, many observational, experimental, and analytical approaches have bee...
The Toxicology Investigators Consortium 2020 Annual ReportNARA Subscribed
Leadership: a New Frontier in Conservation ScienceNARA Subscribed
Leadership is a critical tool for expanding the influence of conservation science, but recent advances in leadership concepts and practice remain underutilized by conservation scientists. Furthermore, an explicit conceptual foundation and definition of leadership in conservation science are not available in the literature. Here we drew on our diverse leadership experiences, our reading of leadership literature, and discussions...
CorrectionNARA Subscribed
Previous1Next