M. Fletcher results 231
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This study investigates how food availability aligns with nutritional requirements of the snail Lunella smaragda , a potential biological control agent for managing biofouling in recreational vessel hubs. Biofouling communities were assessed during two contrasting seasons to gain insights into the quantity and quality of food available for agent consumption. Nutritional availability was higher in spring/summer and increased wi...
Resurrecting habitat fragmentation as a process over timeNARA Subscribed
Capelin ( Mallotus spp.) are pelagic forage fishes that can be especially abundant in sub‐arctic marine ecosystems and are important prey for upper trophic‐level consumers. Abundance and distribution of capelin have been linked to ocean temperature, but the magnitude and directionality of thermal sensitivity can vary regionally. We used data spanning two decades (2002–2022) from autumn surface trawl surveys in three Alaska lar...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Anaemic Streams: Iron and Essential Trace Metals Frequently Limit Primary Producer BiomassNARA Subscribed
Metals are essential for microbial metabolism, yet their role as limiting nutrients in freshwater streams remains poorly understood. We quantified the prevalence of metal and nutrient (co‐)limitation of primary producers in 41 streams. Metal limitation was widespread with Fe limitation eliciting the strongest and most consistent biomass responses (50% of streams). Zn limitation was also common (33% of streams), marking the fir...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The availability and ingestion of microplastics by an intertidal fish is dependent on urban proximityNARA Subscribed
Investigating the impacts of the plastics on our environment, and the potential adverse effects on fauna, has become increasingly important. While a number of studies have shown that microplastic levels in sediments generally increase with proximity to urban regions, fewer studies have investigated how vertebrate ingestion rates vary with urban proximity. Here we explore how urban proximity influences plastic abundance in sedi...
Biochemical composition of biofilms and gastropod grazers; informing biological control efforts from a nutritional perspectiveNARA Subscribed
Considerable interest exists in the development of marine biological control (biocontrol) approaches to biofouling management. For most conceivable applications, the effectiveness of biocontrol at an operational scale is largely unproven, and considerable knowledge gaps and challenges remain. An important consideration for any biocontrol application is whether control agents will persist and remain effective over a reasonable...
Ketogenic Diet-Induced Alterations in Neuronal Signaling-Related Proteins are Not Due to Differences in Synaptosome Protein LevelsNARA Subscribed
Impaired cognitive function is a hallmark of advancing age, and the potential to reverse or delay these cognitive deficits through dietary intervention holds promise for improving quality of life for older adults. Specifically, ketogenic diets (KDs) have now been widely used for the treatment of several neurological and peripheral disorders, including diseases profoundly affecting cognitive health, of which advanced age is the...