APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...

Scleractinian cold-water corals (CWC) rely on benthic currents for the delivery of food and other resources that support their growth and subsequent mound development in the deep sea. However, the CWC-current relationship remains poorly understood, as current knowledge is predominantly derived from spatially constrained ex-situ experimentation and coarse-scale modeling. Therefore, we combined long-term in situ acoustic Doppler...

Human–carnivore coexistence is essential for biodiversity conservation, yet measuring the attitudes and behaviors that support it remains methodologically challenging. We developed psychometric scales to assess willingness to coexist with carnivores and the underlying beliefs of this coexistence through an iterative expert elicitation process grounded in risk perception theory and moral psychology to ensure strong content vali...

Rice is cultivated on approximately 1,000,000 ha in the Mediterranean area, with production concentrated in Egypt, Italy, Türkiye, Spain, Grece and Portugal. In these areas, rice is traditionally established by wet seeding and cultivated under continuous flooding (WFL), which requires larger volumes of water compared to other irrigation practices. The aim of this study is to benchmark irrigation methods alternative to WFL acro...

Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...

The aim of this study is to investigate the association of neutrophil extracellular traps (NETs) markers with clinical and radiological outcomes in acute ischemic stroke (AIS) patients undergoing endovascular thrombectomy (EVT) and assess the effect of periprocedural heparin during EVT on NETs markers and their association with outcomes. From 198 AIS patients included in the MRCLEAN-MED trial, randomized to receive EVT with (...

Key message L atent environmental effects of genotype by environment interactions could be predicted from observed environmental covariates. Predictions into the wider target population of environments revealed greater insights. Abstract Wheat is grown across a diverse range of environments in Australia with contrasting environmental constraints. Targeted breeding to optimise genotypes in target environments is hindered by lar...

Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality’s invasive nature. This study substantially expands the subject pool compared to existing literature, to create a mult...