Weiss-Kruszka syndrome (WSKA; OMIM 618619) is a rare autosomal dominant neurodevelopmental disorder caused by haploinsufficiency of ZNF462, a zinc-finger transcription factor involved in chromatin regulation and early embryonic development. WSKA is characterized by developmental delay, hypotonia, craniofacial dysmorphic features (around 8) and variable congenital anomalies. Genome-wide DNAm profiling was performed on periphera...

Acetylcholine (ACh), a potential neurotransmitter, shows growth and stress responses in plants. Despite, the underlying mechanisms of how ACh mitigates salt toxicity in pepper plants remains to be fully elucidated. Here, pepper plants pre-treated with different concentrations of ACh (0, 50 and 100 µM) were subjected to salinity stress (150 mM NaCl) to investigate their morpho-physiological, biochemical, and molecular alteratio...

This study introduces vacuum compression molding (VCM) as a novel, solvent-free method for fabricating palonosetron hydrochloride (PAL HCl)-loaded polyvinyl alcohol (PVA) microneedles (MNs), addressing limitations of conventional micromolding such as extended drying times, batch variability, and solvent residues. PAL HCl-a hydrophilic 5-HT3 receptor antagonist (MW: 332.85 g/mol) with a low therapeutic dose-was selected for its...

Coastal estuaries are hotspots of biogeochemical cycling, biodiversity, and sediment processing, yet the drivers of carbon cycle processes remain poorly constrained. Here, we elucidate the influence of hydrological connectivity on carbon biogeochemistry in the Indian Sundarban over successive monsoon seasons by comparing hydrologically connected channels with perennial freshwater flow to channels isolated from feeding rivers....