M. Gu results 198
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The interplay between systolic and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) progression is unclear. First-phase ejection fraction (EF1), a sensitive marker of early systolic function, aids in assessing systolic-diastolic relationships in human hypertension and aortic stenosis. This study examines temporal changes in these relationships in mouse models of HFpEF and elevated afterload. Mous...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Global warming intensifies regional precipitation imbalances that disrupt cropland nitrogen cycling and threaten food security. Here, we show that global croplands respond asymmetrically to future precipitation change. Under a middle of the road scenario for 2050, 78% of croplands are projected to become wetter, increasing yields by 15% but raising nitrogen losses by 45%. The remaining 22% that become drier would experience a...
Integrating expert range maps and opportunistic occurrence records of marine fish species in range estimatesNARA Subscribed
Species distribution models (SDMs) are commonly used to estimate species’ geographic distributions to inform biodiversity assessments and conservation planning. However, despite their growing popularity, range predictions of SDMs are affected by biases in opportunistic occurrence records and the lack of information on range limits. Integration of expert range maps in SDMs could help, but this strategy is still rarely used, esp...
Bidirectional prognostic predictions of conversion and reversion in amnestic mild cognitive impairmentNARA Subscribed
Amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) are closely related. While some aMCI patients convert to AD (conversion), some revert to age-appropriate cognitive functioning (reversion). Early identification of these bidirectional trajectories informs aMCI-AD pathology and aids patient management. Data from 129 aMCI participants in the Alzheimer’s Disease Neuroimaging Initiative, who either converted or...
Plants grown from different propagules can develop different architectures that influence their functioning. Hybrid potato ( Solanum tuberosum ) plants grown from true seeds and seedling tubers differ in architectural development, particularly in spatiotemporal distribution of leaves, generating variations in leaf age across leaf positions and origins (main stem or branch). This may affect nitrogen distribution and leaf photos...
Temporal analyses of germ cell mutations using the MutaMouse model support the recommended design in OECD test guideline 488NARA Subscribed
The Organisation for Economic Co-operation and Development test guideline (TG) 488 uses transgenic rodent models to assess in vivo mutagenesis. TG 488 recommends 28 consecutive days of exposure with sampling of germ cells from seminiferous tubules 28 days post-exposure (i.e., 28 + 28d). We analyzed mutant frequencies (MF) in male germ cells up to 70 days post-exposure to determine whether designs other than 28 + 28d are necess...
Differences in predictions of marine species distribution models based on expert maps and opportunistic occurrencesNARA Subscribed
Species distribution models (SDMs) are important tools for assessing biodiversity change. These models require high‐quality occurrence data, which are not always available. Therefore, it is increasingly important to determine how data choice affects predictions of species’ ranges. Opportunistic occurrence records and expert maps are both widely used sources of species data for SDMs. However, it is unclear how SDMs based on the...