M. H. Engel results 54
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Cancer Risk and Mortality Following Kaposi Sarcoma Among People with HIV in the United States, 2000 to 2019NARA Subscribed
People with HIV (PWH) have increased Kaposi sarcoma (KS) risk. Among 2,645 PWH with KS in the United States HIV/AIDS Cancer Match Study, subsequent cancer risk was elevated 2.8-fold (95% confidence interval [CI]: 2.4–3.3) compared to PWH without KS. Mortality after KS declined 2000–2002 and 2012–2015 (hazard ratio = 0.64; 95%CI: 0.55–0.74).
Geography and ecology shape the phylogenetic composition of Amazonian tree communitiesNARA Subscribed
Aim Amazonia hosts more tree species from numerous evolutionary lineages, both young and ancient, than any other biogeographic region. Previous studies have shown that tree lineages colonized multiple edaphic environments and dispersed widely across Amazonia, leading to a hypothesis, which we test, that lineages should not be strongly associated with either geographic regions or edaphic forest types. Location Amazonia. Taxon A...
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytesNARA Subscribed
Activation of the ATP-gated P2X7 receptor (P2X7R), implicated in numerous diseases of the brain, can trigger diverse responses such as the release of pro-inflammatory cytokines, modulation of neurotransmission, cell proliferation or cell death. However, despite the known species-specific differences in its pharmacological properties, to date, most functional studies on P2X7R responses have been analyzed in cells from rodents o...
A 1500‐year record of North Atlantic storm flooding from lacustrine sediments, Shetland Islands (UK)NARA Subscribed
Severe storm flooding poses a major hazard to the coasts of north‐western Europe. However, the long‐term recurrence patterns of extreme coastal flooding and their governing factors are poorly understood. Therefore, high‐resolution sedimentary records of past North Atlantic storm flooding are required. This multi‐proxy study reconstructs storm‐induced overwash processes from coastal lake sediments on the Shetland Islands using...
Objective Workplace health promotion programs (WHPPs) have shown to be effective in improving lifestyle behaviors of employees. Despite potential benefits for employees, participation rates are generally low. The aim of this study was to gain deeper insight into barriers and facilitators for participation in WHPPs prior to implementation according to employees. Methods Peer-to-peer interviewing, a method derived from citizen s...
Geographic patterns of tree dispersal modes in Amazonia and their ecological correlatesNARA Subscribed
Aim To investigate the geographic patterns and ecological correlates in the geographic distribution of the most common tree dispersal modes in Amazonia (endozoochory, synzoochory, anemochory and hydrochory). We examined if the proportional abundance of these dispersal modes could be explained by the availability of dispersal agents (disperser‐availability hypothesis) and/or the availability of resources for constructing zoocho...
Seagrass ecosystem multifunctionality under the rise of a flagship marine megaherbivoreNARA Subscribed
Large grazers (megaherbivores) have a profound impact on ecosystem functioning. However, how ecosystem multifunctionality is affected by changes in megaherbivore populations remains poorly understood. Understanding the total impact on ecosystem multifunctionality requires an integrative ecosystem approach, which is especially challenging to obtain in marine systems. We assessed the effects of experimentally simulated grazing i...
Past failures of monocultures, caused by wind-throw or insect damages, and ongoing climate change currently strongly stimulate research into mixed-species stands. So far, the focus has mainly been on combinations of species with obvious complementary functional traits. However, for any generalization, a broad overview of the mixing reactions of functionally different tree species in different mixing proportions, patterns and u...
Latitude, temperature, and habitat complexity predict predation pressure in eelgrass beds across the Northern HemisphereNARA Subscribed
Latitudinal gradients in species interactions are widely cited as potential causes or consequences of global patterns of biodiversity. However, mechanistic studies documenting changes in interactions across broad geographic ranges are limited. We surveyed predation intensity on common prey (live amphipods and gastropods) in communities of eelgrass ( Zostera marina ) at 48 sites across its Northern Hemisphere range, encompassin...