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NARA Subscribed2
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Springer Nature2
Journal
Archives of Toxicology2
Publication Year
20261
20251
M. Halaczkiewicz results 2 · Newest (Page 1/1, per page 25)
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Author: M. Halaczkiewicz ×Clear All Filters
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Formation and persistence of estragole-derived DNA adducts in human liver cells and tissueNARA Subscribed
Archives of Toxicology · 2026 · Vol. 100 · Issue 7 · Springer
G. Ackermann; M. Abel-Beckmann; C. Quarz; M. Halaczkiewicz; S. Stegmüller; E. Richling; G. Manolikakes; M. Christmann; J. H. Küpper; D. Schrenk; J. Fahrer
Estragole (ES) is a phenylpropene naturally occurring in various herbs and spices, such as fennel and basil. Humans are exposed to ES via the diet or herbal medicinal products. Following its gastrointestinal resorption, hepatic bioactivation of ES by Cytochrome P450 monooxygenases (CYPs) and sulfotransferases (SULTs) can lead to DNA adduct formation and liver cancer in rodents. Up to now, no data is available on ES-dependent D...
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Molecular dosimetry of estragole and 1′-hydroxyestragole-induced DNA adduct formation, clastogenicity and cytotoxicity in human liver cell modelsNARA Subscribed
Archives of Toxicology · 2025 · Vol. 99 · Issue 9 · Springer
G. Ackermann; M. Peil; C. Quarz; A. Schmidt; M. Halaczkiewicz; A. D. Thomas; S. Stegmüller; E. Richling; G. Manolikakes; M. Christmann; J. H. Küpper; D. Schrenk; J. Fahrer
The phenylpropene estragole (ES) is found in essential oils of herbs and spices, such as bitter fennel and basil. Humans are exposed to ES through the diet and phytomedicines. After its absorption, ES undergoes metabolic activation by CYP1A2 and SULT1A1 in the liver, which can give rise to DNA adducts and hepatocarcinogenesis. Until now, quantitative genotoxicity data for ES in human liver cells are scarce, correlating DNA add...
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