M. Hard results 14
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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Genomic and phenotypic effects of inbreeding across two different hatchery management regimes in Chinook salmonNARA Subscribed
Genomic approaches permit direct estimation of inbreeding and its effect on fitness. We used genomic‐based estimates of inbreeding to investigate their relationship with eight adult traits in a captive‐reared Pacific salmonid that is released into the wild. Estimates were also used to determine whether alternative broodstock management approaches reduced risks of inbreeding. Specifically, 1,100 unlinked restriction‐site associ...
Quantifying variation in killer whale ( Orcinus orca) morphology using elliptical Fourier analysisNARA Subscribed
In the northeastern Pacific Ocean, there are three “ecotypes” of killer whales that differ in diet, ecology, behavior, acoustics, genetics, and morphology. Previous attempts to describe the morphological differences among populations of killer whales ( Orcinus orca ) have been limited to descriptive accounts or categorical studies. We used elliptical Fourier analysis (EFA) to quantify shape differences of dorsal fins and pigme...
Three different [ NiFe ] hydrogenases confer metabolic flexibility in the obligate aerobe M ycobacterium smegmatisNARA Subscribed
Summary M ycobacterium smegmatis is an obligate aerobe that harbours three predicted [ NiFe ] hydrogenases, Hyd 1 ( MSMEG _2262–2263), Hyd 2 ( MSMEG _2720‐2719) and Hyd 3 ( MSMEG _3931‐3928). We show here that these three enzymes differ in their phylogeny, regulation and catalytic activity. Phylogenetic analysis revealed that Hyd 1 groups with hydrogenases that oxidize H 2 produced by metabolic processes, and Hyd 2 is homologo...
Widespread population extirpations and the consequent loss of ecological, genetic, and life‐history diversity can lead to extinction of evolutionarily significant units (ESUs) and species. We attempted to systematically enumerate extinct Pacific salmon populations and characterize lost ecological, life history, and genetic diversity types among six species of Pacific salmon (Chinook [ Oncorhynchus tshawytscha ], sockeye [ O ....
Action learning: hierarchical organization and perspectiveNARA Subscribed
Information developed during recently completed evaluations of the status of seven species of anadromous Pacific salmonids ( Oncorhynchus spp.) in the Pacific Northwest was used to characterize patterns of intraspecific diversity along three major axes: ecology, life history and biochemical genetics. Within the study area, the species’ ranges, and therefore the number of distinct ecological regions inhabited differ considerabl...
A novel orthotopic model of breast cancer metastasis to boneNARA Subscribed
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