M. Hauser results 104
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Introduction Arctic warming has resulted in substantial decreases in sea ice and a longer open-water season. This is occurring concurrently with changes in Bering-Chukchi-Beaufort bowhead whale seasonal movements and increasing vessel traffic through Bering Strait, which may increase strike risk. Methods To assess vessel traffic relative to bowhead whale distributions before (2013/14–2016/17), during (2017/18), and after (2018...
Urban coastal lagoons are heavily impacted by untreated sewage, industrial effluents and diffuse pollution, heightening ecotoxicological risks. Herein, Nile tilapia ( Oreochromis niloticus ) was employed as a sentinel species concerning metal exposure at the Jacarepaguá Lagoon Complex (JLC), a critical case of ecological degradation under intense anthropogenic pressure in Rio de Janeiro, Southeastern Brazil. Samplings were con...
Single-cell transcriptomics of acetaminophen-induced responses in human 2D and 3D liver microtissuesNARA Subscribed
Drug-induced liver injury remains a major obstacle in pharmaceutical development and a leading cause of acute liver failure, underscoring the need for predictive and human-relevant in vitro models. Acetaminophen, a widely used analgesic with well-characterized dose-dependent hepatotoxicity, serves as a benchmark compound for evaluating liver toxicity mechanisms. Here, we applied single cell RNA sequencing to characterize cellu...
Rare phenotypes of white coat color in Simmental calves: genetic causes of syndromic forms of albinism and depigmentationNARA Subscribed
The aim of this study was to investigate three unrelated Simmental calves with atypical white coat color, identify potential genetic causes using a trio-based whole-genome sequencing approach, and assess the prevalence of the identified variants in the breed. Several inherited alleles affecting coat color, ranging from fawn to red spotted and white-headed, have been described in Simmental cattle originating from Switzerland. H...
Macrofauna accelerates nutrient cycling through litterfall in cocoa agroforestry systemsNARA Subscribed
This study aimed to better understand nitrogen (N), phosphorus (P), and potassium (K) cycling through litterfall in smallholder cocoa agroforestry systems and to assess if these nutrient flows can be measured using standard litterbags. Annual litter production, relative mass loss, and nutrient loss rates from cocoa leaf litter were evaluated in three farms in south-western Nigeria with and without macrofauna access. Litterfall...
Differential effects of fentanyl compared to morphine on neuroinflammatory signaling in the brain in EcoHIV-infected miceNARA Subscribed
HIV-associated neurocognitive disorders (HAND) pose significant challenges, particularly in individuals with comorbid opioid use disorder (OUD). Fentanyl, a potent synthetic opioid, is a leading contributor to opioid-related fatalities, yet its effects in the context of HIV remain poorly understood. This study investigated the differential impacts of fentanyl and morphine on neuroinflammatory signaling, blood–brain barrier (BB...
Divergent Population Structure in Five Common Rockfish Species of Puget Sound, WA Suggests the Need for Species‐Specific ManagementNARA Subscribed
Quantifying connectivity between endangered or threatened marine populations is critical information for management and conservation, especially where abundance and productivity differ among such populations. Spatial patterns of such connectivity depend not only on extrinsic factors such as oceanography and bathymetry but also on intrinsic species‐specific factors such as life history, demography and the location of glacial re...
Towards a Model-Based Interpretation of Measurements of Mineralogical and Chemical CompositionsNARA Subscribed
We introduce a new methodology for inference of fluid composition from measurements of mineralogical or chemical compositions, expanding upon the use of reactive transport models to understand hydrothermal alteration processes. The reactive transport models are used to impute a latent variable explanatory mechanism in the formation of hydrothermal alteration zones and mineral deposits. An expectation maximisation algorithm is...
Microstructure development in lacustrine, fine-grained sediments traced by in situ and laboratory testingNARA Subscribed
Soil microstructure, often defined as the combination of particle arrangement and bonding, can strongly influence the stiffness and strength of sedimentary deposits. As undisturbed soil sampling is a challenging task in fine-grained soils, seismic in situ testing is becoming increasingly more important to investigate its mechanical behaviour. The aim of this article is to evaluate the influences of sediment depositional age an...