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Recent Advances in Bioanalytical Methods for Quantification and Pharmacokinetic Analyses of Antibody–Drug ConjugatesNARA Subscribed
Antibody–drug conjugates (ADCs) represent a rapidly expanding class of therapeutics, uniquely combining the specificity of monoclonal antibodies with the potency of cytotoxic small-molecule payloads. Due to their inherent structural complexity and heterogeneous composition, accurate characterization and quantification of ADCs pose significant bioanalytical challenges. This review discusses recent advancements in bioanalytical...
Land and ocean ecosystems are strongly connected and mutually interactive. As climate changes and other anthropogenic stressors intensify, the complex pathways that link these systems will strengthen or weaken in ways that are currently beyond reliable prediction. In this review we offer a framework of land–ocean couplings and their role in shaping marine ecosystems in coastal temperate rainforest (CTR) ecoregions, where high...
An 11 hours survey was performed on the 17th of September 2014 in the Rhine Region Of Freshwater Influence (Rhine-ROFI) about 10 km downstream of the mouth of the Rotterdam Waterway during calm weather conditions. Suspended Particle Matter (SPM) measurements were performed during a full tidal cycle, near the seabed, at neap tide, and samples were taken at 0.6 meter above bed for on-board analysis. The measurements were perform...
Actinidia seed-borne latent virus (ASbLV, Betaflexiviridae) is transmitted paternally and maternally at high ratesNARA Subscribed
Actinidia seed-borne latent virus (ASbLV, Betaflexiviridae , genus Prunevirus) was detected at high frequency in healthy seedlings grown from lines of imported seed in a New Zealand post-entry quarantine facility. To determine the route and efficiency of transmission of ASbLV in this dioecious crop species, we developed a rapid molecular protocol and identified a reliable progeny plant tissue to determine paternal and maternal...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
How climate constrains species’ distributions through time and space is an important question in the context of conservation planning for climate change. Despite increasing awareness of the need to incorporate mechanism into species distribution models ( SDM s), mechanistic modeling of endotherm distributions remains limited in this literature. Using the American pika ( Ochotona princeps ) as an example, we present a framework...
Aim To test whether within‐species and among‐species patterns of abundance and latitudinal range in marine bacteria resemble those found for macro‐organisms, and whether these patterns differ along latitudinal clines. Location Global pelagic marine environments. Methods Taxon‐specific sequence abundance and location were retrieved from the open‐access V6‐ rRNA pyrotag sequence data base VAMPS ( http://vamps.mbl.edu/ ), which h...
Extensive clonal spread and extreme longevity in saw palmetto, a foundation clonal plantNARA Subscribed
The lack of effective tools has hampered out ability to assess the size, growth and ages of clonal plants. With Serenoa repens (saw palmetto) as a model, we introduce a novel analytical framework that integrates DNA fingerprinting and mathematical modelling to simulate growth and estimate ages of clonal plants. We also demonstrate the application of such life‐history information of clonal plants to provide insight into managem...
An integrative approach to understanding microbial diversity: from intracellular mechanisms to community structureNARA Subscribed
Ecology Letters (2010) 13: 1073–1084 Abstract Trade‐offs have been put forward as essential to the generation and maintenance of diversity. However, variation in trade‐offs is often determined at the molecular level, outside the scope of conventional ecological inquiry. In this study, we propose that understanding the intracellular basis for trade‐offs in microbial systems can aid in predicting and interpreting patterns of div...