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Iron is an important micronutrient required by marine microorganisms. The Southern Ocean is an ecosystem where primary production is limited by the availability of iron, but how microorganisms in this region adapt to low‐iron conditions or respond to episodic iron inputs is understudied. We tested how external iron additions would impact bacterial production of siderophores during phytoplankton growth using shipboard incubatio...
Leveraging Pharmacy Education through a Train-the-Trainer Model to Enhance Breast Cancer Literacy in Rural CommunitiesNARA Subscribed
Rural versus urban communities experience disproportionate challenges in breast cancer outcomes, with higher breast cancer mortality and later stage disease presentation, despite similar diagnosis rates. These disparities are driven by structural barriers, including rural hospital closures, transportation difficulties, and limited access to oncology specialists. This study evaluated a train-the-trainer program designed to equi...
Lynch syndrome caused by a pathogenic SINE-VNTR-Alu (SVA) insertion in MSH2 gene identified by long-read DNA sequencingNARA Subscribed
Lynch syndrome, the most common hereditary cancer syndrome, is caused by germline pathogenic variants in DNA mismatch repair (MMR) genes. Identifying complex or structural MMR gene pathogenic variants can be challenging with short-read sequencing resulting in patients with unexplained MMR-deficient tumours. In this study, we report multiple members of a family who developed MSH2-deficient tumours where clinical multi-gene pane...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Response of Soil Chemistry to Long-Term Occupancy by Introduced Pinus Species in Hardwood ForestsNARA Subscribed
Conifers have been widely planted to stabilize soils and promote site recovery on former hardwood sites that were cleared for agriculture. Decades of confer occupancy may have lasting effects on nutrient availability, organic matter cycling, soil acidity, and soil buffering capacity. In many areas of eastern North America, conifer plantings consisted of non-native Pinus species planted on abandoned agricultural land that was o...
Marialite (Na 3 Al 3 Si 9 O 24 ·NaCl), the chloride end-member of the scapolite mineral group, is important for determining the chloride content of a paleofluid from which Cl-bearing scapolite formed as well as its potential role in the geochemical cycling of chlorine in tectonically active zones. Experiments on the upper-pressure stability of synthetic marialite breaking down to jadeite + coesite + halite at high pressures we...
Noble and base metal distribution and processes affecting ore tenors in the disrupted lower stratigraphy of the Stillwater Complex, USANARA Subscribed
Exploration continues for contact-style Ni-Cu sulfide and chromitite-associated PGE mineralization in ultramafic rocks of the Stillwater Complex. At the Iron and Chrome Mountain areas, massive sulfides occur along the complex’s footwall contact and anomalous concentrations of PGE+Au are associated with the three lowermost chromitite seams. Southeast of Chrome Mountain, magmatic layering is highly disrupted by the presence of f...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
In 2023, more than half of olive harvests ( Olea europaea ) across Spain, Greece, and Türkiye were lost to drought. The same year late freeze destroyed 90% of the peach crop ( Prunus persica ) on the Georgia Piedmont and the apple crop ( Malus domestica ) in central New York, Vermont, and southern Quebec. Climate extremes now rank with the costliest threats to agriculture, but their role in forest recovery from diebacks that a...
The germline MLH1 c.-42 C > T (rs41285097) promoter variant has been identified in cases with MLH1-deficient colorectal or endometrial cancers but remains a variant of uncertain significance. Genetic testing identified two new MLH1 c.-42 C > T index cases from Australia and the USA. Clinicopathologic and molecular characterisation of tumour and non-neoplastic tissues was performed to investigate the potential mechanism of path...
Floods and fires are part of the ecological regime in many wetlands, yet their interconnectedness is poorly explored. Climate extremes, such as droughts and heatwaves, are increasing fire frequency and intensity, while changing rainfall patterns make floods more unpredictable. These events shape wetland physiognomy, species composition, and functioning. Different wetlands experience varying fire exposure; seasonally inundated...