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Archives of Toxicology · 2023 · Vol. 97 · Issue 3 · Springer
Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm s...
International Archives of Occupational and Environmental Health · 2018 · Vol. 91 · Issue 8 · Springer
Purpose The aim of this study was to get a first overview of the exposure to the solvents and reproductive toxicants N -methyl-2-pyrrolidone (NMP) and N -ethyl-2-pyrrolidone (NEP) in Germany. NMP and NEP metabolite concentrations were determined in 540 24-h urine samples of the German Environmental Specimen Bank collected from 1991 to 2014. With these data we were able to investigate NMP/NEP exposures over time and to evaluate...