Biallelic KIF1C variants are associated with a spectrum of neurological phenotypes, including spasticity, cerebellar ataxia, chorea, and dystonia. Most reported patients involve single-nucleotide variants, whereas copy number variants (CNVs) have been described only once in the PubMed-listed literature. The therapeutic potential of deep-brain stimulation (DBS) in KIF1C -related disease has not yet been evaluated. We report a p...

Purpose This study analyzed the inter-session reliability of the parallel back squat during one-repetition-maximum (1RM) testing in elite youth soccer players and to exploratorily evaluate the consistency with which the prescribed squat depth is achieved. Methods The sample comprised 47 male soccer players (age: 18.1 ± 2.3 years, body mass: 72.4 ± 7.7 kg, height: 1.83 ± 0.06 m) from German youth soccer academy teams competing...

Spatial synchrony, the tendency for temporal fluctuations in an ecological variable to be positively associated in different locations, is a widespread and important phenomenon in ecology. Understanding of the nature and mechanisms of synchrony, and how synchrony is changing, has developed rapidly over the past 2 decades. Many recent developments have taken place through the study of long‐term data sets. Here, we review and sy...

Between 1992 and 2018, the breeding population of Adélie penguins around Anvers Island, Antarctica declined by 98%. In this region, natural climate variability drives five‐year cycling in marine phytoplankton productivity, leading to phase‐offset five‐year cycling in the size of the krill population. We demonstrate that the rate of change of the Adélie breeding population also shows five‐year cycling. We link this population r...

In addition to providing animals with a source of directional or ‘compass’ information, Earth’s magnetic field also provides a potential source of positional or ‘map’ information that animals might exploit to assess location. In less than a generation, the idea that animals use Earth’s magnetic field as a kind of map has gone from a contentious hypothesis to a well-established tenet of animal navigation. Diverse animals rangin...

The relationship between River Ammer flood frequency variability, extreme summer climate over Europe, and solar forcing is investigated. First, we used observational data to evaluate extreme weather and climate anomaly patterns associated with flood and solar forcing as well as the possible dynamical mechanisms behind them. Then, the annual resolution flood layer record from the Lake Ammer sediments is analysed to evaluate mil...

We investigate the respective role of variations in subpolar deep water formation and Nordic Seas overflows for the decadal to multidecadal variability of the Atlantic meridional overturning circulation (AMOC). This is partly done by analysing long (order of 1000 years) control simulations with five coupled climate models. For all models, the maximum influence of variations in subpolar deep water formation is found at about 45...