Declines in nicotinamide adenine dinucleotide (NAD+) are linked to metabolic stress accompanying aging and disease. While precursor-based approaches elevate systemic NAD, their clinical translation can be constrained by biosynthetic bottlenecks and first-pass metabolism. RENEWAL-NAD+ (ClinicalTrials.gov NCT07336836; retrospectively registered 01/04/2026) was a double-blind, randomized, placebo-controlled Phase 0/1b trial in he...

The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This study describes the development of a digital PCR assay for the rapid detection of BA.2.86 and its descendant lineages,...

Red mark syndrome (RMS) is a skin disorder affecting rainbow trout ( Oncorhynchus mykiss ). The present work aimed to correlate the gross skin lesions affecting 46 fish sampled from farms surveyed for RMS with their microscopic features, identifying histological parameters that may be suggestive of disease progression. Skin lesions were grossly included in one of three categories (types I, II and III) according to the progress...

Red mark syndrome ( RMS ) and US strawberry disease ( US SD ) are skin disorders affecting rainbow trout farmed in Europe and USA . The disease etiology has not yet been established. In spite of specific investigations, identifying Rickettsia ‐like organism ( RLO )‐ and Midichloria ‐like organism ( MLO )‐related DNA in affected individuals, these pathogens have never been observed. We performed histological, ultrastructural an...