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Use of translational fusions to express functional Klebsiella oxytoca dinitrogenase reductase in plant mitochondriaNARA Subscribed
Engineering crop plants with the biological nitrogen fixation pathway is a longstanding goal of modern agriculture. Dinitrogenase reductase (NifH) is a critical component of the biological nitrogen fixation pathway, with multiple roles in metal cofactor assembly and catalysis. This enzyme must be folded correctly as a soluble homodimer and loaded with the [4Fe-4S] metallocluster for function. Previous studies have found that K...
Introduction Dietary exposure to melamine (MELA) adversely affects growth performance and intestinal health in Nile tilapia. This study evaluated the protective effects of Crataegus sinaica leaf extract (CSL) against MELA-induced toxicity. Methods In this study, a total of 240 fish (26.39 ± 0.22) were randomly assigned to four groups (60 fish/group; four replicates of 15 fish each). The control group received a basal diet, the...
Herbal-based additives are now recognized as effective tools of growth and immunity in aquaculture. Seeking these botanical alternatives is a practical necessity for sustainable farming and chemical reduction. Moringa oleifera flowers (MOF), in particular, offer significant potential due to their established history in treating inflammation and respiratory conditions. However, the potential of these additives to enhance growth...
Fusarium oxysporum , the causal agent of root rot and vascular wilt in common bean ( Phaseolus vulgaris ), represents a substantial risk to legume cultivation. The current study offers a comparative examination of the antifungal efficacy of agro-industrial wastes from cumin ( Cuminum cyminum ), anise ( Pimpinella anisum ), and banana peel ( Musa paradisiaca ), and their green-synthesized silver nanoparticles (AgNPs), against F...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...