M. Meier results 134
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A human PBMC-based new approach method reveals PFAS-driven T-cell proliferation and immune dysregulationNARA Subscribed
Immunotoxicity has emerged as a key health concern for per- and polyfluoroalkyl substances (PFAS), with animal studies showing reduced T-dependent antibody responses (TDAR) and epidemiological studies reporting decreased vaccine antibody titres. Notably, immunotoxicity is considered one of the most sensitive endpoints for PFAS exposure and has been used to inform regulatory guidance and health-based values. Given that more tha...
Temperate Forest Floors: Ecosystem Hubs in Transition?NARA Subscribed
The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...
Chemicals in plastics differentially affect the transcriptome of MCF-7 breast cancer cellsNARA Subscribed
Humans are exposed to chemicals that leach from plastics, yet many remain data-poor and lack toxicological evaluation. High-throughput transcriptomics (HTTr) provides a scalable way to screen chemicals and generate mechanistic insights relevant to human health risk assessment. We applied HTTr in MCF-7 breast cancer cells to assess chemicals across several concentrations (0.001–50 µM) used in plastics and dyes. Transcriptomic p...
Movements throughout the full annual cycle of three migratory swift species breeding in the LevantNARA Subscribed
Movements throughout the annual cycle evolved as an adaptation to seasonality across different bird species with a continuum of migration strategies and behaviours at the non-breeding range. Swifts are particularly mobile, aerial insectivores with a distinctive lifestyle. However, the spatiotemporal properties of swift migration, including timing, routes, and non-breeding movements, remain poorly understood in populations from...
Developing Self Care Digital Trainings for Cancer Patients: An Implementation Research Project with Broad Stakeholder EngagementNARA Subscribed
Cancer-related fatigue and sleep problems are common and burdensome symptoms affecting many cancer patients. Mind Body Medicine techniques, such as acupressure and mindfulness-based techniques, have been shown to be effective in alleviating these symptoms. However, opportunities for patients to learn and apply these self care techniques are limited. This study aimed to develop two digital training programs to enable cancer pat...
High-throughput transcriptomics analysis of equipotent and human relevant mixtures of BPA alternatives reveal additive effects in vitroNARA Subscribed
While many jurisdictions have phased out use of bisphenol A (BPA), there is increasing exposure to mixtures of BPA alternatives. Like BPA, some alternatives perturb nuclear hormone receptors and are endocrine disruptors. We used high-throughput transcriptomics (HTTr) to evaluate the potency and modes of action of seven mixtures of BPA alternatives and their 12 individual components in breast cancer cells. Our aim was to explor...
Associations of alternative cannabis product use and poly-use with subsequent illicit drug use initiation during adolescenceNARA Subscribed
Rationale Specific cannabis products may differentially increase risk of initiating non-cannabis illicit drug use during adolescence. Objective To determine whether ever- and poly-use of smoked, vaporized, edible, concentrate, or blunt cannabis products are associated with subsequent initiation of non-cannabis illicit drug use. Methods High school students from Los Angeles completed in-classroom surveys. The analytic sample (...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Drivers of nest site selection and breeding success in an Alpine ground-nesting songbirdNARA Subscribed
Birds breeding in high-Alpine habitats must select a suitable breeding site and achieve successful reproduction within a restricted time. During four breeding seasons, we monitored nest sites of the Northern Wheatear ( Oenanthe oenanthe ), a high-Alpine long-distance migrant. We investigated how ecological factors predicted the selection of a site for nesting within the home range, using conditional logistic regression. Birds...
Given its crucial contribution to organismal development and adaptation, gene expression is subject to stringent regulation. With light as an inducer, reversible, noninvasive, spatiotemporally precise, and automatable expression control is reached. We advance circuits that target transcription or translation; respond to blue, red, or infra-red light; and afford pronounced regulatory responses. Alone or combined, these setups u...
Climate variability in marine environments, particularly sea surface temperature (SST), is influenced by natural fluctuations occurring at various temporal and spatial scales. Distinguishing between anthropogenic climate change trends and natural variability is crucial for understanding the complex dynamics of ocean temperatures. This study applies the concept of Time of Emergence (ToE) to estimate when the signal of long-term...
Objective Metabolomics measurements of eccrine sweat may provide novel and relevant biomedical information to support predictive, preventive and personalised medicine (3PM). However, only limited data is available regarding metabolic alterations accompanying chemotherapy of breast cancer patients related to residual cancer burden (RCB) or therapy response. Here, we have applied Metabo-Tip, a non-invasive metabolomics assay bas...