Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...

This study evaluated the effects of providing 3–15 kg of a soluble and biodegradable biopolymer-based enrichment material (blend of biodegradable polymers and natural fibers) to prepartum sows housed in farrowing crates. Fifteen sows were blocked by body weight and backfat thickness and assigned to three treatments: no enrichment material (CONT), 3 kg of enrichment material (BN3), or 15 kg of enrichment material with added nut...

Pathogenic fungi that cause rust adversely affect plants, including crops, affecting them differentially depending on the cultivar. This is the case of blackberry ( Rubus spp.), a member of Rosaceae, introduced in Brazil by Embrapa during the 1980s and 1990s. Given the advantageous nutritional properties of its fruits and the relatively low management costs associated with its cultivation, blackberry production has emerged as...

Background and Aims For Azospirillum to promote plant growth, successful colonization of the associated plant is required. However, the factors governing the interaction between Azospirillum and plants remain unknown. Methods To examine these associations, a deletion mutant strain of Azospirillum brasilense FP2 was constructed by targeting the narL-like gene, which is highly expressed in bacteria colonizing wheat roots. We the...

The Southwestern Atlantic Ocean (SWAO) is an important feeding and developmental area for loggerhead turtle ( Caretta caretta ). However, long-term patterns of resource use across life stages and sexes remain poorly understood for the species in this region. Here, we used stable isotope analysis (SIA) of sequential layers of carapace scutes to investigate resource use of loggerhead turtles in the SWAO across life stages and se...

A new species of Hyphessobrycon is described from a tributary of Rio Jatuarana, lower Rio Aripuanã basin, Rio Madeira basin, Apuí, Amazonas. The new species is part of the Hyphessobrycon agulha lineage, with the typical midlateral narrow black stripe immediately followed dorsally by an iridescent stripe. Its phylogenetic position is corroborated by the DNA barcoding methodology, which also indicates the new species as closely...

Purpose The European Medicines Agency (EMA) guideline Declaration of Storage Conditions in the Product Information of Medicinal Products (CPMP/QWP/609/96/Rev.2) was last revised in 2007. Since then, advances in stability science, increased climatic variability, and evolving regulatory expectations have highlighted limitations in the framework, particularly the use of vague descriptors such as “room temperature” or “no special...

Drought is a major constraint to plant growth and productivity, and rising atmospheric CO₂ concentrations are expected to modify plant responses to water limitation. However, how CO₂ enrichment reshapes the physiological, metabolic, and molecular regulation of specialized metabolite production under drought remains poorly understood. Here, we investigated the combined effects of elevated CO₂ (e[CO₂]) and drought on plant morph...

Schistosomiasis, a complex chronic intravascular parasitic disease caused by Schistosoma mansoni , triggers a multifaceted host immune response and drives endothelial cells toward a sustained proinflammatory phenotype. The dysfunctional endothelial cells are a hallmark event that contributes to intestinal and liver damage mainly due to an increased monocyte adhesion, but the elevated morbidity unveils the lack of knowledge abo...