M. Mulder results 144
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Tracking biodiversity in changing Arctic waters: insights from eDNA metabarcoding in SvalbardNARA Subscribed
Monitoring biodiversity patterns and their changes in Arctic coastal ecosystems is critical under ongoing climate change. However, common current approaches require high effort and expertise and this in turn limits the spatial and temporal scale of these monitoring efforts. Here, we investigated both the fish and the marine invertebrate communities across Svalbard using a multi-marker environmental DNA metabarcoding approach....
Molecular characterization of Cdh12-SCON conditional knockout mice reveals unexpected splicing changesNARA Subscribed
Functional validation of candidate genes in congenital anomalies of the kidneys and urinary tract (CAKUT) and other disorders is essential for translating genetic discoveries into clinical applications. Conditional knockout mouse models are indispensable for studying gene function in complex organ systems. The Short Conditional intrON (SCON) system accelerates the generation of such models by inserting the artificial SCON into...
There are high expectations that agricultural practices can mitigate climate change and improve soil health by increasing soil organic carbon (SOC) stocks. However, existing large scale SOC monitoring treats agricultural management as a black box, meaning that observed patterns and trends cannot inform on the option space of agricultural practices to improve or deteriorate SOC stocks. Here, we combine for the first time manage...
Within patient horizontal gene transfer dynamics of a blaNDM−7 plasmid among four different bacterial speciesNARA Subscribed
Purpose We describe the case of a 73-year old male who was found to be a carrier of an bla NDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca , Raoultella planticola and Serratia marscescens . Resu...
Herbivory can alter plant stoichiometry generating biogeochemical feedbacks that stabilize or drive transitions between ecosystem states. We report results after 23 years from a grazing experiment in Norway comparing five paired exclosures and grazed plots that were complemented with inclusion of five islands serving as a natural control. We tested the hypothesis that herbivory-driven shifts in plant dominance scale to alter e...
Marine sterols from brown seaweeds, particularly fucosterol and its oxidized derivative saringosterol, have shown therapeutic potential for Alzheimer’s disease (AD) and cardiovascular diseases. Here, we aimed to elucidate the cellular and in vivo mechanisms underlying their beneficial effects. In human HepG2 hepatocytes and CCF-STTG1 astrocytoma cells, we assessed liver x receptor (LXRα /LXRβ) activation, sterol uptake, and ef...
Objective (s) Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with first-trimester placental development is unknown. This study investigates associations between maternal angiogenic factors and utero-placental vascular volume (uPVV) and utero-placental vascular skeleton (uPVS) as novel imaging markers of volumetric and morphologic (branching) development of the f...
Effect of training sample size, sampling design and prediction model on soil mapping with proximal sensing data for precision limingNARA Subscribed
Site-specific estimation of lime requirement requires high-resolution maps of soil organic carbon (SOC), clay and pH. These maps can be generated with digital soil mapping models fitted on covariates observed by proximal soil sensors. However, the quality of the derived maps depends on the applied methodology. We assessed the effects of (i) training sample size (5–100); (ii) sampling design (simple random sampling (SRS), condi...