Marine sterols from brown seaweeds, particularly fucosterol and its oxidized derivative saringosterol, have shown therapeutic potential for Alzheimer’s disease (AD) and cardiovascular diseases. Here, we aimed to elucidate the cellular and in vivo mechanisms underlying their beneficial effects. In human HepG2 hepatocytes and CCF-STTG1 astrocytoma cells, we assessed liver x receptor (LXRα /LXRβ) activation, sterol uptake, and ef...

The investigation of the toxic potential of a newly introduced herbicide, Florpyrauxifen-benzyl (FPX), on Nile tilapia ( Oreochromis niloticus ) was the aim of this study. For 96 h, the median lethal concentration (LC 50 ) was assessed in fish juveniles using the Probit analysis following the exposure to five concentrations of FPX (2–3 ppm). For investigating some mechanisms of FPX toxicity, fish were allocated into three grou...