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Longitudinal Impacts of Forest Loss on Bartonella and Hemotropic Mycoplasma Dynamics in Vampire Bats Within a Fragmented HabitatNARA Subscribed
Habitat fragmentation can negatively impact wildlife, including increasing infectious disease risk. We assessed spatiotemporal changes in pathogen dynamics in vampire bats ( Desmodus rotundus ) in response to habitat fragmentation using general linear mixed models to investigate the influence of site, year, and tree cover on Bartonella spp. and hemotropic Mycoplasma spp. (hemoplasmas) infection risk in bats in one large and on...
Role of funders in embedding tests in conservation practiceNARA Subscribed
Effective conservation practice requires decisions based on reliable and relevant evidence, but significant gaps in the evidence base exist. Incorporating well‐designed tests of the effectiveness of interventions for biodiversity in conservation projects is one of the best ways to scale up the rate of evidence generation. Funders of conservation projects are uniquely positioned to support and incentivize such tests as part of...
Lake sturgeon ( Acipenser fulvescens ) growth and longevity estimated from adult capture–mark–recapture dataNARA Subscribed
Effective fishery management policy depends on accurate life‐history data, particularly for harvested species. Longevity is a core life‐history trait that is directly related to annual survival and lifetime reproductive potential, but fish longevity is generally not well documented, particularly for long‐lived species. We used capture–mark–recapture data spanning 44 years as an alternative method to estimate sex‐specific adult...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Gait speed and domain-specific cognitive performance in a diverse cohort of the oldest-old: the LifeAfter90 StudyNARA Subscribed
Gait speed is a robust marker of health in older adults and is associated with cognition, yet few studies have examined this in the oldest-old and if there are differences by cognitive domain. We examined the association between gait speed and cognition across three domains in individuals aged 90 + , considering differences by gender and device use. Then, 502 participants were included from the LifeAfter90 Study. Baseline gait...
Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee LoadingNARA Subscribed
Purpose To investigate temporal evolution of cartilage strain and relaxometry following ACL reconstruction, and examine associations between MRI metrics, pain, and knee loading patterns during gait as potential early markers of cartilage degeneration. Methods Twenty-five participants (15 female, 10 male; mean age 25.6 years) undergoing ACL reconstruction completed MRI assessments at 6 and 12 month post-surgery, including displ...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...