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Five years of national airborne pollen monitoring in South Africa: biome-specific calendars to inform allergy diagnosis and preventionNARA Subscribed
Pollen monitoring is crucial for understanding seasonal patterns, supporting allergy diagnosis and informing early warning tools to mitigate allergic diseases. The Southern Hemisphere lacks long-term pollen seasonal data, with extremely few records from Africa. We present pollen calendars based on five years of data from South Africa. Airborne pollen from 2019 to 2024 across South African biomes was collected in seven cities u...
Purpose Unrecognized contraindications pose risks for adverse drug reactions, hospitalizations or death. Clinical decision support systems (CDSS) aim to mitigate medication-related harm, particularly originating from contraindications. However, many CDSS provide limited benefit, as they focus largely on singular risk situations such as drug-drug interactions and often generate alerts of limited clinical relevance. Comprehensiv...
Temperate Forest Floors: Ecosystem Hubs in Transition?NARA Subscribed
The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...
Mirtazapine is an atypical tetracyclic antidepressant drug that binds to several monoamine neurotransmitter receptors. For instance, mirtazapine binds to H 1 -histamine receptors in vitro and in the brain of patients in vivo. Here, we hypothesize that mirtazapine is an antagonist at human cardiac H 1 -histamine receptors. To test this hypothesis, we measured force of contraction in isolated electrically stimulated (1 Hz) left...
Viral transfer from managed pollinators potentially threatens wild pollinators and may be exacerbated by land‐use changes. Our causal models and plant‐pollinator network data from 48 European urban and agricultural landscapes revealed the ecological mechanisms underpinning viral transmission. Host identity, network architecture and land‐use modulated viral dynamics (black queen cell virus, BQCV; deformed wing virus, DWV‐A and...
Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoonNARA Subscribed
Nutrient availability drives community structure and ecosystem processes, especially in tropical lagoons that are typically oligotrophic but often receive allochthonous inputs from land. Terrestrially derived nutrients are introduced to tropical lagoons by surface runoff and submarine groundwater discharge, which are influenced by seasonal precipitation. However, terrigenous inputs presumably diminish along the onshore–offshor...
Clozapine is an atypical antipsychotic (neuroleptic) drug. Clozapine binds to H 2 -histamine receptors in vitro. We wanted to test the hypothesis that clozapine might be a functional antagonist at human cardiac H 2 -histamine receptors. To that end, we studied isolated electrically stimulated left atrial preparations and spontaneously beating right atrial preparations from transgenic mice with cardiomyocyte-specific overexpres...
There are ongoing debates among different stakeholders about which forest and ungulate management strategies will sustain high levels of timber and animal harvest and maintain important ecosystem functions under climate change. Ungulate-forest interactions are complex, including periods where forest regeneration is sensitive to browsing pressure, making it difficult to predict the consequences of a given strategy over time. To...
Collective behavior diverges independently of the benthic-limnetic axis in sticklebackNARA Subscribed
Comparing populations across replicate environments or habitat types can help us understand the role of ecology in evolutionary processes. If similar phenotypes are favored in similar environments, parallel evolution may occur. Collective behavior, including collective movement and social networks, can play a key role in the adaptation by animals to different environments. However, studies exploring the parallelism of collecti...
Prevalence of aeroallergen sensitization in a polluted and industrialized area: a pilot study in South Africa’s Vaal TriangleNARA Subscribed
This pioneering study evaluates the prevalence of aeroallergens reactivity among atopic populations living in the Vaal Triangle Airshed Priority Area (VTAPA), South Africa. A total of 138 volunteers (51 males and 87 females), of African, colored, white, and Asian ethnicity, and with a mean (range) age of 22 (18–56) years were participating in the study. The study was conducted on the North-West University (NWU) campus in Vande...
Contractile effects of stimulation of D1-dopamine receptors in the isolated human atriumNARA Subscribed
Dopamine receptors have been claimed not to directly increase contractility in the human heart. Therefore, we performed contraction experiments in isolated electrically driven human atrial preparations (HAP). For comparison, we performed contraction experiments with left atrial preparations of transgenic mice which harbor a cardiac overexpression of human D 1 -dopamine receptors (D 1 -TG). In D 1 -TG, first we noted that dopam...