Despite growing recognition that natural rewards can mitigate stress responses, the underlying neurobiological mechanisms remain poorly understood. Here, we examined whether limited sucrose intake (LSI), a paradigm of repeated natural food reward, induces structural plasticity in parvalbumin-expressing (PV+) interneurons and their perineuronal nets (PNNs) within the medial prefrontal cortex (mPFC), a key region involved in str...

An increasing number of systematic reviews and meta-analyses examine health outcomes from traumatic brain injury (TBI). This umbrella review examines the association of TBI with comorbid health outcomes and evaluates the methodological rigor of existing literature. This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO; Registration No. CRD42024581341). EMBASE, PubMed, MEDLINE,...

Orthologs are fundamental for enabling comparative genomics analyses that further our understanding of eukaryotic biology. The unprecedented increase in the availability of high-quality eukaryotic genomes necessitates scalable and accurate methods for orthology inference. The National Center for Biotechnology Information (NCBI) developed “NCBI Orthologs”, a resource and a computational pipeline designed to meet this challenge...