Brown adipose tissue (BAT) activity in humans is linked to better glucose metabolism and cardiometabolic health. In mice, cold exposure increases circulating succinate and enhances BAT thermogenesis, but whether similar succinate responses occur in humans remains undetermined. We analysed data from 33 young (18–25 years), sedentary adults (20 women) from the ACTIBATE cohort (NCT02365129). Plasma succinate was measured enzymati...

Mediterranean Quercus woodlands are socio-ecological systems where biodiversity associated with tree-related microhabitats remains poorly known despite its potential importance for ecosystem functioning and conservation. Tree cavities, in particular, provide buffered microclimates and key nesting and shelter resources for numerous taxa, yet the diversity of organisms associated with these microhabitats remains incompletely doc...

This study explored the relationship between serum cadmium (Cd), smoking exposure, and migraine in the ELSA-Brasil cohort (2008–2010). The analysis included 2,750 participants whose serum Cd levels were measured using inductively coupled plasma mass spectrometry. Smoking exposure was assessed using self-report data of active smoking and second-hand smoke. Migraine, including definite and probable migraine, was diagnosed accord...

Cylindrospermopsin is a potent cyanobacterial toxin of growing global concern due to its environmental persistence and broad toxicological profile. Despite increasing evidence of its toxic effects, knowledge of its toxicokinetics remains limited. This study integrates in silico ADMET predictions with in vitro microsomal assays using human and sex-stratified rat liver microsomes to characterize CYN biotransformation. In silico...

This study compares reproduction and genetic traits of Cistus heterophyllus subsp. carthaginensis in two Iberian Peninsula populations (Murcia and Valencia), alongside C. albidus , the main competitor responsible for hybridisation in these populations. The former taxon is critically endangered (IUCN CR), justifying the conservation efforts. Thermal time, base temperature, hydrotime, base water potential, and seed longevity (th...