Background Currently, no single biomarker can reliably identify preclinical Alzheimer’s disease (AD), particularly at or before the mild cognitive impairment (MCI) stage. Given the heterogeneity of MCI, integrative approaches are needed to improve early risk stratification. Objectives (i) To derive robust latent cognitive components from a multicenter, clinically defined MCI cohort using principal component analysis (PCA); (ii...

Background and aims Reforestation is widely promoted to mitigate soil degradation and desertification in semi-arid Mediterranean regions under future climate-change scenarios. The argan tree ( Argania spinosa ), a drought-resistant species, has been proposed as a potential alternative to pine ( Pinus halepensis). Methods We assessed soil physicochemical properties, organic matter (SOM) characteristics (content, molecular compo...

The Southwestern Atlantic Ocean (SWAO) is an important feeding and developmental area for loggerhead turtle ( Caretta caretta ). However, long-term patterns of resource use across life stages and sexes remain poorly understood for the species in this region. Here, we used stable isotope analysis (SIA) of sequential layers of carapace scutes to investigate resource use of loggerhead turtles in the SWAO across life stages and se...

Monoclonal antibodies (mAbs) are promising therapeutic agents for neurological disorders due to their high specificity. However, their clinical application is significantly hindered by their poor transport across the blood-brain barrier (BBB) and their limited diffusion within the brain parenchyma. While significant efforts have been oriented to tackle the first barrier, the challenge of efficient brain diffusion remains large...

Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...