Weiss-Kruszka syndrome (WSKA; OMIM 618619) is a rare autosomal dominant neurodevelopmental disorder caused by haploinsufficiency of ZNF462, a zinc-finger transcription factor involved in chromatin regulation and early embryonic development. WSKA is characterized by developmental delay, hypotonia, craniofacial dysmorphic features (around 8) and variable congenital anomalies. Genome-wide DNAm profiling was performed on periphera...

The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...

Petrochronology with garnet and monazite was performed on refurbished metapelite samples from the Central Kaoko Zone (CKZ), the Western Kaoko Zone (WKZ) and the Orogenic Core Zone (OCZ). P-T path segments of garnet crystallisation were reconstructed by geothermobarometry based on continuous cation exchange and net transfer reactions. The oldest metamorphic monazite populations of 1490 ± 15 Ma and 635 ± 7 Ma occur enclosed in g...

Background and Objectives: Friedreich ataxia (FA) causes progressive impairment of communication due to gradual deterioration of speech, associated with impaired hearing, socio-cognitive and language skills. There is an urgent need to investigate the impact of this multiparametric alteration on patients’ lives. Therefore, the COMunication and ATAXia measure (COMATAX) was developed and validated in French and German. Methods: I...

The European Kupferschiefer Province contains multiple sedimentary rock hosted copper (SRC) deposits and has been mined for many centuries. The formation of the SRC deposits has been described by various genetic models, which primarily differ in terms of the timing of ore stage sulfide formation relative to host rock deposition (i.e., syn-genetic vs. epigenetic). In this study, samples from two drill cores in the Spremberg-Gra...

Coastal sediments are globally significant sources and sinks of greenhouse gases (GHGs), yet their contributions to climate feedbacks of warming and ocean acidification remain uncertain, in part due to limited understanding of short‐term variability. Here, we use a fully factorial laboratory experiment to disentangle how diel light–dark and tidal inundation and exposure interact with warming and elevated p CO 2 to regulate ben...

Permeable sands on continental shelves host microbial communities that drive organic carbon turnover, oxygen fluxes and nitrogen loss. Advective porewater flow associated with sedimentary bedforms maintains these rates and fluxes. Modeling and laboratory studies suggest that advective porewater flow is tightly coupled to bedform stability. However, the impacts of in situ bedform stability on biogeochemical fluxes in subtidal s...

Introduction Marine mammals are apex predators in the marine environment and seals are known as opportunistic hunters which adapt to prey availability in their distribution range. Knowledge about harbour seal diet is a crucial baseline parameter to assess environmental change in marine ecosystems, however inferring diet composition in marine animals remains challenging. The harbour seal subpopulations in the German North Sea a...

Energetic resources within organisms fuel both parasite growth and immune responses against them, but it is unclear whether energy allocation is sufficient to explain changes in infection outcomes under the threat of multiple parasites. We manipulated diet in flour beetles ( Tribolium confusum ) infected with two natural parasites and used a combination of transcriptomic and phenotypic assays to investigate the role of resourc...