Recurrent pregnancy loss (RPL) is a multifactorial reproductive disorder that affects approximately 1–5% of couples of reproductive age and is associated with considerable emotional and clinical burden. Although several genetic, anatomical, endocrine, infectious, and thrombophilic factors have been implicated, the underlying cause remains unexplained in nearly half of all cases, highlighting the importance of immune dysregulat...

Toll-like receptors (TLRs) are the best characterized family of Pattern Recognition Receptor-targeting adjuvants. Activation of TLR7/8 in particular, enhances antigen presentation by dendritic cells and macrophages, boosting Th1-mediated adaptive immune responses. However, poor pharmacokinetics and systemic toxicity of some TLR7/8 ligands hinder their clinical translation. Lipidation and incorporation of TLR7/8 ligands into li...

The genetic diversity and variation of three pseudo‐species of the commercially important Indian conch Turbinella pyrum from the southeast coast of India were studied. A total of 88 individuals was genotyped at 12 loci and differences in the genetic diversity among genetic groups were correlated with known population histories. The study identified 535 alleles and all the studied loci were highly polymorphic. The number of all...