Background Human pluripotent stem cells (hPSCs) offer a promising source of hepatocytes for disease modeling and drug screening. However, hepatocytes derived in conventional two-dimensional (2D) cultures often exhibit incomplete maturation, limiting their physiological relevance. The molecular mechanisms underlying the improved differentiation observed in three-dimensional (3D) culture systems remain poorly understood. Results...

Climate change is a major threat to biodiversity, and migratory animals are particularly vulnerable, due partly to their reliance upon good resource availability across a network of sites at specific times. Migrants perform vital ecosystem functions, transferring significant resources across large spatial scales, but the impacts of climate change on the ability of individuals to complete these journeys are poorly studied. Coll...

Amphipods play an important role in Southern Ocean trophic chains. Considering the key role of Pacific Ocean and sea ice ecosystems in the Earth system and the growing impact of global environmental change, it is important to collect information on the status of marine amphipod biodiversity. A total of 410 zooplankton samples were collected by BIONESS (Bedford Institute of Oceanography Net Environmental Sampling System) from 2...