Phase shifts can occur in ecosystems because of external stressors. Such transitions from one state (e.g., clear water, seagrass) to another (e.g., phytoplankton blooms, bare substrate) continue to be documented worldwide. In estuaries, stressors related to urban and suburban development are often implicated in phase shifts, including altered hydrology and eutrophication. Tidal creeks may be especially prone to phase shifts as...

Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....