Objective and design This study investigated the antinociceptive potential and mechanisms of Protectin DX (PDX) in a KO 2 -induced inflammatory pain. Treatment Male mice received PDX (1, 3, or 10 ng) or vehicle (0.7% ethanol in sterile saline) intraperitoneally (i.p.), 1 h before KO 2 (30 µg intraplantar [i.pl.] or 1 mg [i.p.]). Methods Upon KO 2 injection, evoked (mechanical and thermal hyperalgesia, and mechanical allodynia)...

Objective Trans -Chalcone (TC) is an anti-inflammatory flavonoid that reduces hyperalgesia by targeting nuclear factor κB and inflammasome in gout arthritis model. However, a direct modulation of nociceptors by TC has never been investigated, which was the aim of the present study. Methods Experimental models of overt pain-like behaviors were applied as the stimuli-induced behavior depends, at least in part, on nociceptive neu...