The latest hypothesis regarding the source of enhanced neural activation from resistance training is the reticulospinal rather than the corticospinal tract, based on invasive animal and emerging human data. The present study employed a six-week isometric resistance training intervention in a randomized controlled design to address this knowledge gap. Thirty-nine healthy, untrained males (age ~23 y, sustained contraction group...

Vegetation surveys provide key information for evaluating functions within and across estuaries. However, survey methods and analyses are often highly variable, site-specific, and driven by monitoring program goals and objectives, making regional comparisons that include multiple programs difficult. This study compared multiple transect- and quadrat-based vegetation monitoring methods within eight southern California estuaries...

Water scarcity is a critical challenge in West Texas, where agriculture and the oil and gas industry compete for limited water resources. The oil and gas industry generates approximately 32% of the nation’s produced water, presenting significant opportunities for beneficial reuse. This study evaluated polished desalinated produced water (PDPW) as a supplemental irrigation source for field-grown alfalfa in a semi-arid region, w...

Purpose Given the urgency of the cement and concrete industry to decarbonise by 2050, circular economy (CE) strategies are becoming more eminent. This study aims to identify how CE practices can contribute to lowering environmental impacts and in particular greenhouse gas (GHG) emissions in the European Union. As future developments of our socio-economic systems are inherently uncertain, the analysis also considers the effecti...

Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present study examines structure–function relationships—specifically, the relation of hippocampal volume with patterns of temporoparietal effective connectivity—in youth...

The water–energy–food (WEF) nexus approach highlights the interdependence of water, energy and food resources, all of which play central roles in agriculture, especially irrigation. A WEF nexus lens was applied to Mpumalanga's Crocodile River catchment, a vital irrigation area that significantly contributes to South Africa's staple food production. The region faces rising water demand and excessive withdrawals, threatening wat...

AZD1402 (Elarekibep) is a novel anticalin with engineered IL-4Rα antagonist binding properties that was under development for inhaled treatment of asthma. Structural similarity to tear-lipocalin is thought to limit immunogenicity risk; however, a range of treatment-emergent hypersensitivity-like adverse events were observed in a clinical study. This study aimed to (i) explore the activation of drug-exposed human T-cells with A...

Global conservation maps often overlook community lands, impacting decision-making and reducing local agency. We focus on the high-profile and regionally important case of Massaha’s ancestral territory (Ibola Dja Bana Ba Massaha). In Gabon, the forest is largely gazetted into logging concessions and described as an Eden-like wilderness despite long-term human presence. We compare Massaha’s biocultural maps to global, colonial,...

Motivation The database initiated by the Mountain Invasion Research Network (MIREN) is one of the few globally implemented standardized vegetation surveys in mountains. The focus is on collecting plant species occurrences at 5‐year intervals along and adjacent to mountain roads spanning elevational gradients, with the goal of providing critical information about the ongoing spread of non‐native plants and the potential impacts...

Lynch syndrome, the most common hereditary cancer syndrome, is caused by germline pathogenic variants in DNA mismatch repair (MMR) genes. Identifying complex or structural MMR gene pathogenic variants can be challenging with short-read sequencing resulting in patients with unexplained MMR-deficient tumours. In this study, we report multiple members of a family who developed MSH2-deficient tumours where clinical multi-gene pane...

Output from dynamically downscaled, convection‐permitting regional climate simulations is used to examine projected changes in the frequency, timing and spatial distribution of synthetic severe convective storm (SCS) detections based on peril proxies across three 15‐year epochs—1990–2005, 2040–2055 and 2085–2100—under intermediate and pessimistic emissions scenarios, including the first mid‐century projections of SCS activity,...

Elevated carbon dioxide (eCO 2 ) acts as a fertiliser for photosynthesis, driving an increase in gross primary production (GPP). However, it is unclear how effectively increased GPP propagates along the ‘carbon (C) cascade’ to increase net primary production (NPP) and vegetation C stocks ( C veg ) in different plant compartments. Vegetation models were criticised for being overly sensitive to photosynthesis (source‐driven), ne...