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Differential metabolomic effects of progestagen-based estrus synchronisation in South African Dohne Merino ewesNARA Subscribed
This study represents one of the first to comprehensively profile the homeostatic cervicovaginal metabolome of South African Dohne Merino ewes using liquid chromatography high resolution mass spectrophotometry (LC-HRMS) and compare that metabolome immediately after estrus synchronisation using progestagen intravaginal pessaries. As the use of assisted reproductive technologies gains traction in various livestock production sys...
Post-prandial acyl ghrelin infusion in heart failure patients increases gastric emptying rateNARA Subscribed
Acyl ghrelin increases cardiac output (CO) and contractility in patients with heart failure with reduced ejection fraction (HFrEF). In healthy humans, acyl ghrelin increases gastric emptying rate (GER) and hunger, a potential add-on benefit for HFrEF patients suffering from cachexia with symptoms of delayed gastric emptying and loss of appetite. The aim of this study was to determine if post-prandial acyl ghrelin infusion incr...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
The Product User’s Experience of Circular Economy Behaviors: An Interdisciplinary Delphi-Validated ModelNARA Subscribed
Adoption of Circular Economy (CE) behaviors, such as repair and sharing, remains slow, often due to high costs, inconvenience, limited rewards, or social undesirability. Accelerating the sustainability transition requires that consumers, or product users, experience these behaviors as predominantly positive. To address the lack of a comprehensive framework for understanding such experiences, this paper introduces the Product U...
Dynamic cycling and redox transformations of dissolved organic sulfur in the surface oceanNARA Subscribed
The marine dissolved organic sulfur (DOS) pool contains both labile metabolites that are rapidly cycled in the surface ocean and compounds that may persist for thousands of years in the marine environment. Here, we describe the sulfur speciation of marine solid‐phase extracted DOS (DOS SPE ) from the North Atlantic surface ocean, revealing a diversity of oxidation states that include alkyl sulfides, disulfides, aromatics, sulf...
Yellowstone cutthroat trout Oncorhynchus virginalis bouvieri in Yellowstone Lake are the focus of intensive conservation efforts due to the threat of predation by invasive lake trout Salvelinus namaycush . Suppression gillnetting has reduced the abundance of predatory lake trout, and the Yellowstone cutthroat trout population is recovering. Long‐term monitoring indicates the size structure of the population shifted following l...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Evaluating a Tri-Institutional Cancer Research Capacity-Building Program for Early-Stage InvestigatorsNARA Subscribed
The Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) initiative of the National Cancer Institute (NCI) supports long-standing collaborations between an under-resourced institution and NCI-designated Cancer Centers to strengthen cancer research workforce and advance cancer research capacity. One of the longest continuously funded CPACHE programs is the Morehouse School of Medicine/Tuskegee University/Universi...
Developmental transcriptomes predict adult social behaviours in the socially flexible sweat bee, Lasioglossum baleicumNARA Subscribed
Natural variation can provide important insights into the genetic and environmental factors that shape social behaviour and its evolution. The sweat bee, Lasioglossum baleicum , is a socially flexible bee capable of producing both solitary and eusocial nests. We demonstrate that within a single nesting aggregation, soil temperatures are a strong predictor of the social structure of nests. Sites with warmer temperatures in the...
A Review of Abrupt Permafrost Thaw: Definitions, Usage, and a Proposed Conceptual FrameworkNARA Subscribed
Purpose of Review We review how ‘abrupt thaw’ has been used in published studies, compare these definitions to abrupt processes in other Earth science disciplines, and provide a definitive framework for how abrupt thaw should be used in the context of permafrost science. Recent Findings We address several aspects of permafrost systems necessary for abrupt thaw to occur and propose a framework for classifying permafrost process...
Blue carbon ecosystems such as seagrass meadows, mangrove forests, and salt marshes are important carbon sinks that can store carbon for millennia. Recently, organic matter sulfurization and pyritization have been proposed as mechanisms of net carbon storage in blue carbon ecosystems. At our study site, organic sulfur that is resistant to acid hydrolysis (protokerogen) is an order of magnitude less abundant than pyrite sulfur,...