M.D. Bateman results 28
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Anadromous salmonids play vital roles in marine and freshwater ecosystems. The most abundant of these fishes—Pacific salmon ( Oncorhynchus spp.)—are integral to coastal ecosystems and communities across the North Pacific Rim, but numerous populations are experiencing dramatic declines, particularly towards the south of their range. Although many declines have been linked to poor marine survival, the early marine life phase of...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The sedimentary succession at Whittlesey preserves a unique British late Middle Pleistocene to Holocene record back to a time equivalent to at least marine oxygen isotope stage 8 (ca. 250 ka). This study builds on previously published sedimentology, geochronology and palaeoecology results to establish 20 sedimentary facies associations, with 14 of them dated by luminescence, amino acid geochronology or radiocarbon age‐estimate...
New age‐estimate data and implications for marine isotope stage 7 and 5e sea levels in Fenland, eastern EnglandNARA Subscribed
Only one last interglacial relative sea‐level indicator point (SLIP) has been recognised for Fenland, eastern England, and the nearest penultimate interglacial SLIP is located on the north Norfolk coast. Such limited information restricts the regional input to, and hence the relevance of, global reconstructions of late Middle and Late Pleistocene sea level. Marine‐influenced deposits without such relevant data are known in Fen...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
The secret lives of wedgefish: first insights into fine-scale behaviour and movement ecology of a globally imperilled rayNARA Subscribed
Wedgefishes have recently been recognised as one of the most imperilled marine fish families worldwide. However, many knowledge gaps about their biology and ecology hinder conservation efforts. Here we used a combination of acoustic telemetry and acceleration datalogger technology to gain fundamental insights into the fine-scale behaviour, habitat use, size of activity spaces, and residency of adult female bottlenose wedgefish...
Development and characterisation of a novel complex triple cell culture model of the human alveolar epithelial barrierNARA Subscribed
Owing to increased pressure from ethical groups and the public to avoid unnecessary animal testing, the need for new, responsive and biologically relevant in vitro models has surged. Models of the human alveolar epithelium are of particular interest since thorough investigations into air pollution and the effects of inhaled nanoparticles and e-cigarettes are needed. The lung is a crucial organ of interest due to potential expo...
Former proglacial lakes provide insight into the temporal and spatial evolution of past ice sheet dynamics and the glaciohydrological systems associated with them. Glacial Lake Pickering was a proglacial lake in North Yorkshire impounded by the British–Irish Ice Sheet. However, geomorphic evidence for its existence and extent is weak and contested. This paper presents, for the first time, systematic mapping of geomorphic featu...
Maximum extent and readvance dynamics of the Irish Sea Ice Stream and Irish Sea Glacier since the Last Glacial MaximumNARA Subscribed
The BRITICE‐CHRONO Project has generated a suite of recently published radiocarbon ages from deglacial sequences offshore in the Celtic and Irish seas and terrestrial cosmogenic nuclide and optically stimulated luminescence ages from adjacent onshore sites. All published data are integrated here with new geochronological data from Wales in a revised Bayesian analysis that enables reconstruction of ice retreat dynamics across t...
Oust the louse: leaping behaviour removes sea lice from wild juvenile sockeye salmon Oncorhynchus nerkaNARA Subscribed
We conducted a manipulative field experiment to determine whether the leaping behaviour of wild juvenile sockeye salmon Oncorhynchus nerka dislodges ectoparasitic sea lice Caligus clemensi and Lepeophtheirus salmonis by comparing sea‐lice abundances between O. nerka juveniles prevented from leaping and juveniles allowed to leap at a natural frequency. Juvenile O. nerka allowed to leap had consistently fewer sea lice after the...
New age constraints for the limit of the British–Irish Ice Sheet on the Isles of ScillyNARA Subscribed
The southernmost terrestrial extent of the Irish Sea Ice Stream (ISIS), which drained a large proportion of the last British–Irish Ice Sheet, impinged on to the Isles of Scilly during Marine Isotope Stage 2. However, the age of this ice limit has been contested and the interpretation that this occurred during the Last Glacial Maximum (LGM) remains controversial. This study reports new ages using optically stimulated luminescen...
A late Pleistocene–Holocene multi‐proxy record of palaeoenvironmental change from Still Bay, southern Cape Coast, South AfricaNARA Subscribed
The southern Cape is a key focus for southern African palaeoenvironmental research as it represents the transitional region between temperate westerlies and sub‐tropical rainfall sources. This study presents pollen, plant biomarker, geochemical and charcoal data preserved in the Rietvlei wetland. The bulk of the record spans the last 16 ka, but it also provides rare insights into late Marine Oxygen Isotope Stage (MIS) 3 (ca. 3...
Luminescence dating indicates radiocarbon age underestimation in late Pleistocene fluvial deposits from eastern EnglandNARA Subscribed
Robust geochronological control is crucial for interpreting and correlating the environmental record from fragmentary terrestrial sequences from the last glacial period. Traditional terrestrial stratigraphies are typically reliant on radiocarbon dating, although estimates of antiquity for samples older than 40 ka may be unreliable. Optically stimulated luminescence (OSL) dating of sediments is an alternative for dating the who...