M.L. Phillips results 314
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Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...
A primary care pharmacogenetic precision medicine pilot based on specific Māori tribal ethical frameworks and principlesNARA Subscribed
Indigenous tribal communities are frequently underserved by genomic medicine because they are under-represented in research, often live in remote locations and have ethical and cultural perspectives that vary from westernised standpoints. The Rakeiora platform, a permissioning and analytical environment that incorporates Māori perspectives and ethical frameworks on how precision medicine research is best conducted was used to...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Dynamic cycling and redox transformations of dissolved organic sulfur in the surface oceanNARA Subscribed
The marine dissolved organic sulfur (DOS) pool contains both labile metabolites that are rapidly cycled in the surface ocean and compounds that may persist for thousands of years in the marine environment. Here, we describe the sulfur speciation of marine solid‐phase extracted DOS (DOS SPE ) from the North Atlantic surface ocean, revealing a diversity of oxidation states that include alkyl sulfides, disulfides, aromatics, sulf...
Distribution and ecology of the four Macrourus species by‐caught in the longline fishery at South Georgia, Southern OceanNARA Subscribed
Although Macrourus species are the main by‐catch across Southern Ocean longline fisheries, including around South Georgia, the lack of species‐specific data has hindered effective management and ecological understanding. Aggregation of macrourids at genus level masks critical interspecific differences in life‐history strategies and vulnerabilities to fishing. Here, we provide the first comprehensive biological assessment of th...
Purpose In Australia, cervical screening is usually offered face-to-face through primary care. As self-collection offers flexibility in how and where screening can be accessed, we assessed participant preferences for flexible screening models. Methods We recruited women and people with a cervix aged 24–74 years into a national survey (December 2023–April 2024) via a paid Meta campaign and community networks. Sociodemographic f...
Logging intensity alters tree species composition and wood density, but not tree diversity, in lowland forests in VietnamNARA Subscribed
Tropical forests host considerable biodiversity but face degradation from timber extraction (“logging”). We examined how logging intensity affected tree diversity, species composition, community wood density and availability of timber species in a lowland forest in north-central Vietnam. We measured and identified trees in 18 quarter-hectare plots that vary in historical logging intensity. Tree diversity showed no significant...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural populations. To address this gap, we used reduced representation bisulfite sequencing...
Reference genomes from representative species across families provide the critical infrastructure for research and conservation. The Cetacean Genomes Project (CGP) began in early 2020 to facilitate the generation of near error-free, chromosome-resolved reference genomes for all cetacean species. Towards that goal, and using the methods, goals and genome assembly quality standards of the Vertebrate Genomes Project (VGP), we gen...
A species' success during the invasion of new areas hinges on an interplay between the demographic processes common to invasions and the specific ecological context of the novel environment. Evolutionary genetic studies of invasive species can investigate how genetic bottlenecks and ecological conditions shape genetic variation in invasions, and our study pairs two invasive populations that are hypothesized to be from the same...