Purpose Catheter-based total renal denervation (TRDN) has recently gained FDA approval to lower blood pressure in patients with treatment-resistant hypertension. Current TRDN technologies indiscriminately destroy efferent (sympathetic) and afferent (sensory) renal nerves. However, preclinical studies suggest that the beneficial effects of TRDN may be due to ablation of afferent, rather than efferent, renal nerves. We developed...

Diatoms in the Pseudo‐nitzschia genus produce the neurotoxin domoic acid. Domoic acid bioaccumulates in shellfish, causing illness in humans and marine animals upon ingestion. In 2017, high domoic acid levels in shellfish meat closed shellfish harvest in Narragansett Bay, Rhode Island for the first and only time in history, although abundant Pseudo‐nitzschia have been observed for over 60 years . To investigate whether an envi...

Lakes fed by Greenlandic mountain glaciers and ice caps (GICs) contain important archives of Arctic palaeoenvironmental change. GIC proglacial lake records have been increasingly used to reconstruct Holocene glacier behaviour, largely focusing on macrostratigraphy. However, despite the wide range of topographic settings and catchment characteristics, there has been little systematic analysis of the ways that catchment conditio...

Purpose Sheep are the standard preclinical model for assessing safety of novel replacement heart valves, yet the anatomic and pathologic effects of invasive surgery, including those involving cardiopulmonary bypass (CPB), are unknown. Thus, we aimed to determine the gross, hematologic and biochemical effects of sham mitral and aortic replacement valve procedures in sheep to establish a useful control for evaluation of novel re...

Modelling seasonal temperature extremes in weather patterns allows for better forecasting and prediction. Analysis of extreme values over a given time period is usually done by fitting a generalized extreme value (GEV) distribution to the maximum values in the data; however, lack of sufficient weather recordings due to missing data or violation of independence assumptions (block maxima should be over a large time interval) may...

Laboratory studies have demonstrated that the microscopic stages of kelps can rapidly resume development from a delayed state. Like terrestrial seeds or aquatic resting eggs, banks of delayed kelp stages may supplement population recovery after periods of stress, playing an important role for kelp populations that experience adult sporophyte absences due to seasonal or interannual disturbances. We found that removing the micro...