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Springer Nature1
Journal
Molecular Neurobiology1
Publication Year
20251
Madeleine Wacker results 1 · Newest (Page 1/1, per page 25)
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Most L1CAM Is not Associated with Extracellular Vesicles in Human Biofluids and iPSC–Derived NeuronsNARA Subscribed
Molecular Neurobiology · 2025 · Vol. 62 · Issue 8 · Springer
Vaibhavi Kadam; Madeleine Wacker; Patrick Oeckl; Milena Korneck; Benjamin Dannenmann; Julia Skokowa; Stefan Hauser; Markus Otto; Matthis Synofzik; David Mengel
Transmembrane L1 cell adhesion molecule (L1CAM) is widely used as a marker to enrich for neuron-derived extracellular vesicles (EVs), especially in plasma. However, this approach lacks sufficient robust validation. This study aimed to assess whether human biofluids are indeed enriched for EVs, particularly neuron-derived EVs, by L1CAM immunoaffinity, utilizing multiple sources (plasma, CSF, conditioned media from iPSC-derived...
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